Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Perio > 43.Antibiotics in periodontal therapy > Flashcards

43.Antibiotics in periodontal therapy Flashcards

1
Q

Antibiotics in periodontal therapy

Effectiveness of antibiotic therapy depends on

A
  • Capacity of drug to reach infected site
  • Resistance of bacteria/ability to inactivate agent
  • Be maintained at sufficienty high concentration for some time
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Antibiotics in periodontal therapy

Antibiotics classified into

A
  • Bacteriostatic and bactericidal
  • Narrow spectrum and wide spectrum
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Antibiotics in periodontal therapy

Must always precede antimicrobial therapy

A

Mechanical instrumentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Antibiotics in periodontal therapy

Methods of delivery of antibiotics

A
  • Oral
  • Intramuscular/intravenous(serious conditions)
  • Topical
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Antibiotics in periodontal therapy

Allows application of antimicrobial agents at levels that cannot be reached by systemic route

A

Local therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antibiotics in periodontal therapy

Systemic antiobiotics better if

A

Targeted bacteria are distributed wider

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Antibiotics in periodontal therapy

Disadvantages of systemic antibiotic therapy

A
  • Only small portion reaches subgingival microflora
  • Adverse drug reactions greater
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Antibiotics in periodontal therapy

Tetracylines

A
  • Refractory periodontitis, incl. localised aggresive periodontitis
  • Bacteriostatic=>effective against gram positive bacteria
  • Anti-collagenase effect
  • Inhibts growth of A.A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Antibiotics in periodontal therapy

Anticollagenase effect

A

Inhibits tissue destruction and helps with bone regeneration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Antibiotics in periodontal therapy

Can be used due to increased resistance to tetracyclines

A
  • Metranidazole
  • Metranidazole-clavulanic acid
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antibiotics in periodontal therapy

Reason long term use of tetracyclines should be avoided

A
  • Bacterial resistance
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Antibiotics in periodontal therapy

Members of tetracycline group

A
  • Tetracycline
  • Minocycline
  • Doxycyline
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Antibiotics in periodontal therapy

side effects of Tetracycline use

A
  • Photosensitivity
  • Dizziness
  • Headache
  • Tooth discolouration (under12)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Antibiotics in periodontal therapy

Minocycline

A
  • Broad spectrum
  • Suppresses spirochetes and motile rods
  • Similar side effects to tetracycline but increased incidence of vertigo
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Antibiotics in periodontal therapy

Doxycycline

A
  • Broad spectrum(similar to minocycline)
  • Similar side effects to tetracycline
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Antibiotics in periodontal therapy

Most photosensitising agent in tetracycline category

A

Doxycycline

17
Q

Antibiotics in periodontal therapy

Metranidazole

A
  • Bactericidal
  • Effective against anaerobes-porphyromonas gingivalis and prevotella intermedia
  • Uses-Gingivitis, ANUG, Chronic and aggressive periodontitis
18
Q

Antibiotics in periodontal therapy

Metranidazole can be combined with

A
  • Amoxicilin
  • Amoxicilin clavulanate
19
Q

Antibiotics in periodontal therapy

Metranidazole side effects

A
  • Antabuse effect when alcohol ingested- Cramps, nausea, vomitting
  • Inhibits warfarin metabolism
  • Prolongs prothrombin time
  • Metallic taste in mouth
20
Q

Antibiotics in periodontal therapy

Most widley used antibiotic

A

Penicillins

21
Q

Antibiotics in periodontal therapy

Penicillins

A
  • Bactericidal
  • Inhibit bacterial cell wall production
22
Q

Antibiotics in periodontal therapy

Side effects of penicillins

A
  • Allergic reactions
  • Bacterial resistance
23
Q

Antibiotics in periodontal therapy

Amoxicillin

A
  • Semi synthetic penicillin
  • Gram negative and positive bacteria
  • Aggressive periodontitis
  • Susceptible to penicillinase
24
Q

Antibiotics in periodontal therapy

Penicillinase

A

*Beta lactamase that breaks penicillin ring structure=>
* Makes it ineffective

25
Q

Antibiotics in periodontal therapy

Combination of amoxicilin that is resistant to penicilinase enzymes

A

Amoxicillin-clavulanate potassium

26
Q

Antibiotics in periodontal therapy

Beta lactams with similar action and structure to penicillins

A

Cephalosporins

27
Q

Antibiotics in periodontal therapy

Cephalosporins

A
  • Resistant to Betalactamases
  • Not usually used for dental infections
28
Q

Antibiotics in periodontal therapy

Clindamycin

A
  • Anaerobic bacteria
  • Periodontitis
  • Strong affinity for osseous tissue
29
Q

Antibiotics in periodontal therapy

Ciprofloxacin

A
  • Quinolone=>gram negative rods
  • All strains of A.A
  • Minimal effect on streptococcus species
  • Can be combined w/ metronidazole
30
Q

Antibiotics in periodontal therapy

Macrolides

A
  • Inhibit protein synthesis
  • Bacteriostatic and bacteriocidial
  • Erythromycin, spiramycin, azithromycin
31
Q

Antibiotics in periodontal therapy

Can alter electrical activity of heart leading to prolonged QT interval

A

Azithromycin

32
Q

Antibiotics in periodontal therapy

Amoxicilin dose

A
  • 500mg
  • x3 a day for 8 days
33
Q

Antibiotics in periodontal therapy

Azithromycin dose

A
  • 500 mg
  • x1 daily for 4-7 days
34
Q

Antibiotics in periodontal therapy

Ciprofloxacin dose

A
  • 500 mg
  • X2 daily for 8 days
35
Q

Antibiotics in periodontal therapy

Clindamycin dose

A
  • 300 mg
  • x3 daily for 10 days
36
Q

Antibiotics in periodontal therapy

Doxycyline and minocycline dose

A
  • 100 mg to 200 mg
  • x1 daily for 21 days
37
Q

Antibiotics in periodontal therapy

Metronidazole dose

A
  • 500 mg
  • x3 daily for 8 days

Perio (60 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions