4.4_1 Renal I Part II Flashcards

1
Q

In a normal capillary bed, _____ is high pushing out

A

HP

OP

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2
Q

In a peritubular capillary, _____ is very low

A

HP

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3
Q

What does the low HP in peritubular capillaries yield?

A

Net reabsorption of water

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4
Q

OP is a stronger force in peritubular capillaries because of..

A

Proteins

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5
Q

~_____ % of filtrate is immediately captured from the filtrate

A

65

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6
Q

~___% of Na+ ion reabsorption occurs in the proximal tubule via __________ using the ________

A

65
Primary active transport
Na+ / K+ ATPase

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7
Q

Most other ions (Cl-, K+, Ca2+, Mg2+, Pi) are absorbed from the proximal tubule via _______ or _______

A

Facilitated diffusion

Secondary active transport

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8
Q

Glucose and amino acids are reabsorbed by ….

A

Carrier mediated secondary active transport with Na+ ions

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9
Q

Na+ transport across luminal or apical membrane is ______

A

Passive (facilitated diffusion)

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10
Q

Na+ transport across the basolateral membrane is…

A

Active (ATPase pump) creates a low intracellular [Na]

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11
Q

The luminal membrane is closer to / touching the…

A

Tubular fluid

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12
Q

The basolateral membrane is closer to / touching…

A

Interstitial fluid

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13
Q

Glucose and amino acids are transported by what process across the luminal membrane?

A

Secondary active transport (supporter proteins, use Na+ gradient)

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14
Q

Glucose and amino acids cross the basolateral membrane via..

A

Facilitated diffusion

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15
Q

Maximum tubular transport

A

Carrier proteins like the Na / Glucose supporter can saturate if the maximum transport capacity (tubular maximum) is exceeded

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16
Q

Tubular maximum for glucose

A

320 mg / min

17
Q

Tubular secretion is for..

A

Larger, unwanted molecules

18
Q

Tubular secretion is going from the ____ to the ______

A

Blood

Filtrate

19
Q

Tubular secretion is he..

A

Active transfer fo materials from peritubular capillaries to lumen of both the PCT and DCT (filtrate)

20
Q

Two generic carrier systems for tubular secretion

A

Basic carriers

Acidic carriers

21
Q

Basic carriers

A

For basic molecules

ex: dopamine, histamine

22
Q

Acidic carriers

A

For acidic molecules

ex: uric acid, sulfate conjugates, penicillin

23
Q

Tubule cells can modify molecules to make them more…

A

Water soluble and biochemically “inert”

24
Q

Sulfation

A

Steroid hormones get conjugated with SO2- (sulfates)

25
Q

Many hydrophobic molecules also leave the body through…

A

Liver bile

26
Q

Cytochrome enzymes

A

In tubule cells, work to detoxify xenobiotic compound (ex: antibiotic drugs

27
Q

Nephrotoxic

A

Presence of some drugs kills tubule cells

28
Q

Examples of nephrotoxic drugs

A
Amphotericin B (anti fungal)
Cisplatin (Chemo)