418 Seizures and Epilepsy Flashcards

1
Q

Mechanisms of action of phenytoin [2] (H20 C418 P3517)

A

Inhibition of Na+-dependent action potentials in a frequency-dependent manner
Inhibition of voltage-gated Ca2+ channels

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2
Q

Mechanism of action of carbamazepine (H20 C418 P3517)

A

Inhibition of Na+-dependent action potentials in a frequency-dependent manner

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3
Q

Mechanisms of action of lamotrigine [2] (H20 C418 P3517)

A

Inhibition of Na+-dependent action potentials in a frequency-dependent manner
Attenuation of glutamate activity

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4
Q

Mechanisms of action of topiramate [2] (H20 C418 P3517)

A

Inhibition of Na+-dependent action potentials in a frequency-dependent manner
Attenuation of glutamate activity

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5
Q

Mechanism of action of zonisamide (H20 C418 P3517)

A

Inhibition of Na+-dependent action potentials in a frequency-dependent manner

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6
Q

Mechanism of action of lacosamide (H20 C418 P3517)

A

Inhibition of Na+-dependent action potentials in a frequency-dependent manner

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7
Q

Mechanism of action of rufinamide (H20 C418 P3517)

A

Inhibition of Na+-dependent action potentials in a frequency-dependent manner

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8
Q

Mechanisms of action of gabapentin [2] (H20 C418 P3517)

A

Inhibition of voltage-gated Ca2+ channels

Increase in the availability of GABA

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9
Q

Mechanism of action of pregabalin (H20 C418 P3517)

A

Inhibition of voltage-gated Ca2+ channels

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10
Q

Mechanism of action of ezogabine (H20 C418 P3517)

A

Facilitating the opening of potassium channels

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11
Q

Mechanism of action of felbamate (H20 C418 P3517)

A

Attenuation of glutamate activity

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12
Q

Mechanism of action of benzodiazepines (H20 C418 P3517)

A

Potentiation of GABA receptor function

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13
Q

Mechanism of action of barbiturates (H20 C418 P3517)

A

Potentiation of GABA receptor function

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14
Q

Mechanisms of action of valproic acid [2] (H20 C418 P3517)

A

Increase in the availability of GABA

Inhibition of T-type Ca2+ channels in thalamic neurons

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15
Q

Mechanism of action of tiagabine (H20 C418 P3517)

A

Increase in the availability of GABA

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16
Q

Mechanism of action of levetiracetam (H20 C418 P3517)

A

Modulation of release of synaptic vesicles

17
Q

Mechanism of action of brivaracetam (H20 C418 P3517)

A

Modulation of release of synaptic vesicles

18
Q

Mechanism of action of ethosuximide (H20 C418 P3517)

A

Inhibition of T-type Ca2+ channels in thalamic neurons