112 Coagulation Disorders Flashcards
An isolated abnormal prolonged PT suggests deficiency of this factor (H20 C112 P830)
Factor VII
One of the most common hemophilia A mutation, present in 40% of severe hemophilia A (H20 C112 P831)
Inversion of intron 22
Moderate hemophilia corresponds to residual factor activity of: (H20 C112 P831)
1-5%
Most common bleeding manifestation in severe hemophilia (H20 C112 P831)
Recurrent hemarthroses
Large hematomas or bleeds into deep muscles require factor levels of: (H20 C112 P832)
50%
Control of serious bleeds that affect the oropharyngeal spaces, CNS, and the retroperitoneum require sustained factor levels of ___ for ___? (H20 C112 P832)
50-100% for 7-10 days
The major complication of hemophilia treatment (H20 C112 P832)
Formation of alloantibodies to FVIII or FIX
Most effective strategy for eradication of inhibitory antibody (H20 C112 P833)
Immune tolerance induction
Major cause of morbidity and 2nd leading cause of death in hemophilia (H20 C112 P833)
HCV infection
Screening for HCC in hemophilia patients with high risk HCV (H20 C112 P833)
Semiannual or annual ultrasound and alpha fetoprotein
Defined as random inactivation of the X chromosomes (H20 C112 P833)
Lyonization
Factor XI defieciency is more common in these ethnic groups [2] (H20 C112 P833)
Ashkenazi and Iraqi Jews
Most sensitive test for DIC (H20 C112 P835-6)
FDP level
Indicated for chronic DIC, purpura fulminans, during surgical resection of giant hemangiomas, and during removal of dead fetus (H20 C112 P836)
Low dose heparin 5-10 U/kg/hr
Central mechanism of DIC (H20 C112 P835)
Uncontrolled thrombin generation
In liver disease, prolonged TT and normal fibrinogen and FDP levels suggest: (H20 C112 P837)
Dysfibrinogenemia
In liver disease, normal levels of FV and low levels of FVII suggest: (H20 C112 P837)
Vitamin K deficiency
Most effective method of correcting hemostasis in patients with liver failure (H20 C112 P837)
Infusion of FFP
Dose of FFP in liver disease (H20 C112 P837)
5-10 mL/kg
Cryoprecipitate is indicated in liver disease only when fibrinogen levels are less than: (H20 C112 P837)
100 mg/mL
Thrombosis of these veins [2] are common in patients with advanced cirrhosis (H20 C112 P837)
Portal vein, mesenteric vein
Coagulation factor that is the most common target of antibody formation in liver disease (H20 C112 P837)
Factor VIII (a.k.a. Acquired hemophilia A)
Tests [2] that distinguish patients with lupus anticoagulant from those with acquired inhibitor (H20 C112 P838)
Positive DRVVT and hexagonal-phase phospholipids test
