112 Coagulation Disorders Flashcards

1
Q

An isolated abnormal prolonged PT suggests deficiency of this factor (H20 C112 P830)

A

Factor VII

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2
Q

One of the most common hemophilia A mutation, present in 40% of severe hemophilia A (H20 C112 P831)

A

Inversion of intron 22

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3
Q

Moderate hemophilia corresponds to residual factor activity of: (H20 C112 P831)

A

1-5%

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4
Q

Most common bleeding manifestation in severe hemophilia (H20 C112 P831)

A

Recurrent hemarthroses

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5
Q

Large hematomas or bleeds into deep muscles require factor levels of: (H20 C112 P832)

A

50%

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6
Q

Control of serious bleeds that affect the oropharyngeal spaces, CNS, and the retroperitoneum require sustained factor levels of ___ for ___? (H20 C112 P832)

A

50-100% for 7-10 days

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7
Q

The major complication of hemophilia treatment (H20 C112 P832)

A

Formation of alloantibodies to FVIII or FIX

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8
Q

Most effective strategy for eradication of inhibitory antibody (H20 C112 P833)

A

Immune tolerance induction

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9
Q

Major cause of morbidity and 2nd leading cause of death in hemophilia (H20 C112 P833)

A

HCV infection

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10
Q

Screening for HCC in hemophilia patients with high risk HCV (H20 C112 P833)

A

Semiannual or annual ultrasound and alpha fetoprotein

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11
Q

Defined as random inactivation of the X chromosomes (H20 C112 P833)

A

Lyonization

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12
Q

Factor XI defieciency is more common in these ethnic groups [2] (H20 C112 P833)

A

Ashkenazi and Iraqi Jews

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13
Q

Most sensitive test for DIC (H20 C112 P835-6)

A

FDP level

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14
Q

Indicated for chronic DIC, purpura fulminans, during surgical resection of giant hemangiomas, and during removal of dead fetus (H20 C112 P836)

A

Low dose heparin 5-10 U/kg/hr

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15
Q

Central mechanism of DIC (H20 C112 P835)

A

Uncontrolled thrombin generation

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16
Q

In liver disease, prolonged TT and normal fibrinogen and FDP levels suggest: (H20 C112 P837)

A

Dysfibrinogenemia

17
Q

In liver disease, normal levels of FV and low levels of FVII suggest: (H20 C112 P837)

A

Vitamin K deficiency

18
Q

Most effective method of correcting hemostasis in patients with liver failure (H20 C112 P837)

A

Infusion of FFP

19
Q

Dose of FFP in liver disease (H20 C112 P837)

A

5-10 mL/kg

20
Q

Cryoprecipitate is indicated in liver disease only when fibrinogen levels are less than: (H20 C112 P837)

A

100 mg/mL

21
Q

Thrombosis of these veins [2] are common in patients with advanced cirrhosis (H20 C112 P837)

A

Portal vein, mesenteric vein

22
Q

Coagulation factor that is the most common target of antibody formation in liver disease (H20 C112 P837)

A

Factor VIII (a.k.a. Acquired hemophilia A)

23
Q

Tests [2] that distinguish patients with lupus anticoagulant from those with acquired inhibitor (H20 C112 P838)

A

Positive DRVVT and hexagonal-phase phospholipids test