376 Hypothyroidism Flashcards
Most common cause of neonatal hypothyroidism (H20 C376 P2698)
Thyroid gland dysgenesis
Dose of T4 in the initial year of congenital hypothyroidism (H20 C376 P2699)
10-15 mcg/kg/day
Symptoms of hypothyroidism are more readily apparent at TSH levels of: (H20 C376 P2699)
> 10 mIU/mL
Best documented risk factors for autoimmune hypothyroidism (H20 C376 P2699)
HLA-DR polymorphisms
In autoimmune hypothyroidism, thyroid cell destruction is primarily mediated by: (H20 C376 P2700)
CD8+ cytotoxic T cells
Antibodies against TSH-R cause hypothyroidism and thyroid atrophy especially in this population (H20 C376 P2700)
Asian patients
Most common symptoms [2] of hypothyroidism (H20 C376 P2699)
Tiredness, weakness
Most common signs [2] of hypothyroidism (H20 C376 P2699)
Dry coarse skin; cool peripheral extremities
This diagnostic test rules out primary hypothyroidism (H20 C376 P2701)
Normal TSH
Better measure of thyroid function in the months following radioiodine treatment (H20 C376 P2701)
Unbound T4 levels
Usual daily replacement dose of levothyroxine if there is no residual function (H20 C376 P2701)
1.6 mcg/kg
TSH should be measured after how many weeks/months after instituting LT4 treatment or changing LT4 dose? (H20 C376 P2702)
2 months
Full relief of hypothyroid symptoms are usually attained how long after TSH levels are restored? (H20 C376 P2702)
3-6 months
Target TSH in hypothyroid pregnant women (H20 C376 P2702)
<2.5 mIU/mL
During the first half of pregnancy of a hypothyroid patient, it is recommended that thyroid function is evaluated every: (H20 C376 P2702)
4 weeks