376 Hypothyroidism Flashcards

1
Q

Most common cause of neonatal hypothyroidism (H20 C376 P2698)

A

Thyroid gland dysgenesis

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2
Q

Dose of T4 in the initial year of congenital hypothyroidism (H20 C376 P2699)

A

10-15 mcg/kg/day

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3
Q

Symptoms of hypothyroidism are more readily apparent at TSH levels of: (H20 C376 P2699)

A

> 10 mIU/mL

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4
Q

Best documented risk factors for autoimmune hypothyroidism (H20 C376 P2699)

A

HLA-DR polymorphisms

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5
Q

In autoimmune hypothyroidism, thyroid cell destruction is primarily mediated by: (H20 C376 P2700)

A

CD8+ cytotoxic T cells

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6
Q

Antibodies against TSH-R cause hypothyroidism and thyroid atrophy especially in this population (H20 C376 P2700)

A

Asian patients

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7
Q

Most common symptoms [2] of hypothyroidism (H20 C376 P2699)

A

Tiredness, weakness

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8
Q

Most common signs [2] of hypothyroidism (H20 C376 P2699)

A

Dry coarse skin; cool peripheral extremities

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9
Q

This diagnostic test rules out primary hypothyroidism (H20 C376 P2701)

A

Normal TSH

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10
Q

Better measure of thyroid function in the months following radioiodine treatment (H20 C376 P2701)

A

Unbound T4 levels

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11
Q

Usual daily replacement dose of levothyroxine if there is no residual function (H20 C376 P2701)

A

1.6 mcg/kg

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12
Q

TSH should be measured after how many weeks/months after instituting LT4 treatment or changing LT4 dose? (H20 C376 P2702)

A

2 months

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13
Q

Full relief of hypothyroid symptoms are usually attained how long after TSH levels are restored? (H20 C376 P2702)

A

3-6 months

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14
Q

Target TSH in hypothyroid pregnant women (H20 C376 P2702)

A

<2.5 mIU/mL

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15
Q

During the first half of pregnancy of a hypothyroid patient, it is recommended that thyroid function is evaluated every: (H20 C376 P2702)

A

4 weeks

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16
Q

Elderly patients may require __% less thyroxine than younger patients (H20 C376 P2702)

A

20%

17
Q

Loading dose of levothyroxine in myxedema coma (H20 C376 P2702)

A

200-400 mcg

18
Q

Loading dose of liothyronine in myxedema coma (H20 C376 P2702)

A

5-20 mcg

19
Q

External warming is indicated in myxedema coma if temperature drops to: (H20 C376 P2702)

A

<30 C