376 Hypothyroidism

Question 1

Most common cause of neonatal hypothyroidism (H20 C376 P2698)

Answer 1

Thyroid gland dysgenesis

Question 2

Dose of T4 in the initial year of congenital hypothyroidism (H20 C376 P2699)

Answer 2

10-15 mcg/kg/day

Question 3

Symptoms of hypothyroidism are more readily apparent at TSH levels of: (H20 C376 P2699)

Answer 3

> 10 mIU/mL

Question 4

Best documented risk factors for autoimmune hypothyroidism (H20 C376 P2699)

Answer 4

HLA-DR polymorphisms

Question 5

In autoimmune hypothyroidism, thyroid cell destruction is primarily mediated by: (H20 C376 P2700)

Answer 5

CD8+ cytotoxic T cells

Question 6

Antibodies against TSH-R cause hypothyroidism and thyroid atrophy especially in this population (H20 C376 P2700)

Answer 6

Asian patients

Question 7

Most common symptoms [2] of hypothyroidism (H20 C376 P2699)

Answer 7

Tiredness, weakness

Question 8

Most common signs [2] of hypothyroidism (H20 C376 P2699)

Answer 8

Dry coarse skin; cool peripheral extremities

Question 9

This diagnostic test rules out primary hypothyroidism (H20 C376 P2701)

Answer 9

Normal TSH

Question 10

Better measure of thyroid function in the months following radioiodine treatment (H20 C376 P2701)

Answer 10

Unbound T4 levels

Question 11

Usual daily replacement dose of levothyroxine if there is no residual function (H20 C376 P2701)

Answer 11

1.6 mcg/kg

Question 12

TSH should be measured after how many weeks/months after instituting LT4 treatment or changing LT4 dose? (H20 C376 P2702)

Answer 12

2 months

Question 13

Full relief of hypothyroid symptoms are usually attained how long after TSH levels are restored? (H20 C376 P2702)

Answer 13

3-6 months

Question 14

Target TSH in hypothyroid pregnant women (H20 C376 P2702)

Answer 14

<2.5 mIU/mL

Question 15

During the first half of pregnancy of a hypothyroid patient, it is recommended that thyroid function is evaluated every: (H20 C376 P2702)

Answer 15

4 weeks

Question 16

Elderly patients may require __% less thyroxine than younger patients (H20 C376 P2702)

Answer 16

20%

Question 17

Loading dose of levothyroxine in myxedema coma (H20 C376 P2702)

Answer 17

200-400 mcg

Question 18

Loading dose of liothyronine in myxedema coma (H20 C376 P2702)

Answer 18

5-20 mcg

Question 19

External warming is indicated in myxedema coma if temperature drops to: (H20 C376 P2702)

Answer 19

<30 C