093 Iron Deficiency and Other Hypoproliferative Anemias Flashcards
Typical half-clearance time of transferrin-bound iron (H20 C93 P683)
60-90 mins
Half-clearance time of transferrin-bound iron in iron deficiency (H20 C93 P683)
10-15 mins
Average red cell life span (H20 C93 P684)
120 days
Normally, an adult male will need to absorb at least how much of elemental iron daily (H20 C93 P684)
1 mg
Normally, females in childbearing years will need to absorb an average of how much of elemental iron daily (H20 C93 P684)
1.4 mg
The principal iron regulatory hormone (H20 C93 P684)
Hepcidin
Once inside the gut cell, iron may be stored as ferritin or transported through the cell to be released at the basolateral surface to plasma transferrin through: (H20 C93 P684)
Ferroportin
In the process of release, iron interacts with this peroxidase which oxidizes the iron to the ferric form for transferrin binding (H20 C93 P684)
Hephaestin
Serum ferritin levels that are diagnostic of absent marrow iron stores (H20 C93 P685)
<15 μg/L
Hemoglobin synthesis becomes impaired once the transferrin saturation falls to: (H20 C93 P685)
15–20%
Stage of iron deficiency where RBC protoporphyrin and TIBC rises (>380) (H20 C93 P685)
Iron-deficient erythropoiesis
Stage of iron deficiency where serum ferritin decreases (H20 C93 P685)
Negative iron balance
A cardinal rule is that the appearance of iron deficiency in an adult male or post-menopausal female means ___ until proven otherwise. (H20 C93 P685)
Gastrointestinal blood loss
Spooning of the fingernails, a sign of advanced iron deficiency (H20 C93 P685)
Koilonychia
Normal serum iron (H20 C93 P685)
50-150 μg/dL
Normal TIBC (H20 C93 P685)
300-360 μg/dL
Normal transferrin saturation (H20 C93 P685)
25-50%
The most convenient laboratory test to estimate iron stores (H20 C93 P685)
Serum ferritin level
Aside from absolute or relative deficiency, one of the most common causes of increased red cell protoporphyrin levels is: (H20 C93 P686)
Lead poisoning
Laboratory test that most readily distinguishes thalassemias from iron deficiency as a cause of microcytic hypochromic anemia (H20 C93 P686)
Serum iron
Sustained treatment for this duration after correction of anemia is necessary to provide stores of at least 0.5-1 g of iron (H20 C93 P687)
6-12 months
A dose of 200 mg of elemental iron per day should result in the absorption of iron up to: (H20 C93 P686)
50 mg/day
The most prominent complication of oral iron therapy, seen in at least 15-20% of patients (H20 C93 P687)
Gastrointestinal distress
In the iron tolerance test, serum iron should rise to this value 2-3 h after intake of two iron tablets on an empty stomach (H20 C93 P687)
At least 100 μg/dL
Elemental iron content of LMW iron dextran (H20 C93 P687)
1500 mg
Reticulocyte count should begin to increase after how many days after initiation of oral iron therapy (H20 C93 P687)
4-7 days
Often the most distinguishing features between true iron deficiency anemia and anemia of inflammation (H20 C93 P688)
Serum ferritin
Hepcidin is produced in the: (H20 C93 P688)
Liver
This laboratory test may be necessary to confirm chronic blood loss on top of chronic inflammation (H20 C93 P688)
Soluble transferrin protein
Patients with these conditions [2] show a smaller degree of EPO deficiency for a given level of renal failure (H20 C93 P688)
Polycystic kidney disease, hemolytic-uremic syndrome
Patients with these conditions [2] show a more severe EPO deficiency for a given level of renal failure (H20 C93 P688)
Diabetes, myeloma
Usually, a unit of packed red cells increases the hemoglobin level by: (H20 C93 P689)
1 g/dL
Usual dose of EPO in CKD (H20 C93 P689)
50-150 U/kg 3x a week
Dose of EPO in chemotherapy-induced anemia (H20 C93 P689)
300 U/kg 3x a week
