093 Iron Deficiency and Other Hypoproliferative Anemias

Question 1

Typical half-clearance time of transferrin-bound iron (H20 C93 P683)

Answer 1

60-90 mins

Question 2

Half-clearance time of transferrin-bound iron in iron deficiency (H20 C93 P683)

Answer 2

10-15 mins

Question 3

Average red cell life span (H20 C93 P684)

Answer 3

120 days

Question 4

Normally, an adult male will need to absorb at least how much of elemental iron daily (H20 C93 P684)

Answer 4

1 mg

Question 5

Normally, females in childbearing years will need to absorb an average of how much of elemental iron daily (H20 C93 P684)

Answer 5

1.4 mg

Question 6

The principal iron regulatory hormone (H20 C93 P684)

Answer 6

Hepcidin

Question 7

Once inside the gut cell, iron may be stored as ferritin or transported through the cell to be released at the basolateral surface to plasma transferrin through: (H20 C93 P684)

Answer 7

Ferroportin

Question 8

In the process of release, iron interacts with this peroxidase which oxidizes the iron to the ferric form for transferrin binding (H20 C93 P684)

Answer 8

Hephaestin

Question 9

Serum ferritin levels that are diagnostic of absent marrow iron stores (H20 C93 P685)

Answer 9

<15 μg/L

Question 10

Hemoglobin synthesis becomes impaired once the transferrin saturation falls to: (H20 C93 P685)

Answer 10

15–20%

Question 11

Stage of iron deficiency where RBC protoporphyrin and TIBC rises (>380) (H20 C93 P685)

Answer 11

Iron-deficient erythropoiesis

Question 12

Stage of iron deficiency where serum ferritin decreases (H20 C93 P685)

Answer 12

Negative iron balance

Question 13

A cardinal rule is that the appearance of iron deficiency in an adult male or post-menopausal female means ___ until proven otherwise. (H20 C93 P685)

Answer 13

Gastrointestinal blood loss

Question 14

Spooning of the fingernails, a sign of advanced iron deficiency (H20 C93 P685)

Answer 14

Koilonychia

Question 15

Normal serum iron (H20 C93 P685)

Answer 15

50-150 μg/dL

Question 16

Normal TIBC (H20 C93 P685)

Answer 16

300-360 μg/dL

Question 17

Normal transferrin saturation (H20 C93 P685)

Answer 17

25-50%

Question 18

The most convenient laboratory test to estimate iron stores (H20 C93 P685)

Answer 18

Serum ferritin level

Question 19

Aside from absolute or relative deficiency, one of the most common causes of increased red cell protoporphyrin levels is: (H20 C93 P686)

Answer 19

Lead poisoning

Question 20

Laboratory test that most readily distinguishes thalassemias from iron deficiency as a cause of microcytic hypochromic anemia (H20 C93 P686)

Answer 20

Serum iron

Question 21

Sustained treatment for this duration after correction of anemia is necessary to provide stores of at least 0.5-1 g of iron (H20 C93 P687)

Answer 21

6-12 months

Question 22

A dose of 200 mg of elemental iron per day should result in the absorption of iron up to: (H20 C93 P686)

Answer 22

50 mg/day

Question 23

The most prominent complication of oral iron therapy, seen in at least 15-20% of patients (H20 C93 P687)

Answer 23

Gastrointestinal distress

Question 24

In the iron tolerance test, serum iron should rise to this value 2-3 h after intake of two iron tablets on an empty stomach (H20 C93 P687)

Answer 24

At least 100 μg/dL

Question 25

Elemental iron content of LMW iron dextran (H20 C93 P687)

Answer 25

1500 mg

Question 26

Reticulocyte count should begin to increase after how many days after initiation of oral iron therapy (H20 C93 P687)

Answer 26

4-7 days

Question 27

Often the most distinguishing features between true iron deficiency anemia and anemia of inflammation (H20 C93 P688)

Answer 27

Serum ferritin

Question 28

Hepcidin is produced in the: (H20 C93 P688)

Answer 28

Liver

Question 29

This laboratory test may be necessary to confirm chronic blood loss on top of chronic inflammation (H20 C93 P688)

Answer 29

Soluble transferrin protein

Question 30

Patients with these conditions [2] show a smaller degree of EPO deficiency for a given level of renal failure (H20 C93 P688)

Answer 30

Polycystic kidney disease, hemolytic-uremic syndrome

Question 31

Patients with these conditions [2] show a more severe EPO deficiency for a given level of renal failure (H20 C93 P688)

Answer 31

Diabetes, myeloma

Question 32

Usually, a unit of packed red cells increases the hemoglobin level by: (H20 C93 P689)

Answer 32

1 g/dL

Question 33

Usual dose of EPO in CKD (H20 C93 P689)

Answer 33

50-150 U/kg 3x a week

Question 34

Dose of EPO in chemotherapy-induced anemia (H20 C93 P689)

Answer 34

300 U/kg 3x a week