090 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis

Question 1

The presence of Lambert-Eaton myasthenic syndrome should lead to these diagnostic tests (H20 C90 P669)

Answer 1

Chest and abdomen CT or body PET scan

Question 2

Diagnostic tests to consider in patients with peripheral neuropathy of unknown cause (H20 C90 P669)

Answer 2

Serum and urine immunofixation studies

Question 3

Paraneoplastic encephalomyelitis and focal encephalitis are usually associated with this malignancy (H20 C90 P670)

Answer 3

Small cell lung cancer

Question 4

Usual tumor associated with anti-Ma2-associated encephalitis (H20 C90 P670)

Answer 4

Germ cell neoplasm of the testis

Question 5

Tumor associated with encephalitis with NMDA receptor antibodies, especially in female patients >12 years (H20 C90 P671)

Answer 5

Ovarian teratoma

Question 6

Patients with encephalitis with NMDA antibodies above this age are more frequently male (H20 C90 P671)

Answer 6

45 years

Question 7

Electrolyte abnormality associated with encephalitis with leucine-rich LG1 antibodies (H20 C90 P671)

Answer 7

Hyponatremia

Question 8

Syndrome associated with encephalitis with Caspr2 antibodies (H20 C90 P671)

Answer 8

Morvan syndrome

Question 9

Encephalitis with mGluR5 antibodies associated with Hodgkin lymphoma (H20 C90 P672)

Answer 9

Ophelia syndrome

Question 10

Majority of children with opsoclonus-myoclonus syndrome has this underlying malignancy (H20 C90 P672)

Answer 10

Neuroblastoma

Question 11

Hormone than can be used to treat opsoclonus-myoclonus syndrome (H20 C90 P672)

Answer 11

ACTH

Question 12

A search for this malignancy should be undertaken in patients with a rapidly progressive motor neuron syndrome and a monoclonal protein in serum or CSF (H20 C90 P673)

Answer 12

Lymphoma

Question 13

Neuromyelitis optica with this antibody may occur in rare instances as a paraneoplastic manifestation of cancer (H20 C90 P673)

Answer 13

Aquaporin 4

Question 14

The detection of these antibodies suggest concurrent dorsal root ganglionitis in patients with paraneoplastic peripheral neuropathy and anti-CRMP5 antibodies

Answer 14

Anti-Hu

Question 15

Peripheral nerve hyperexcitability or neuromyotonia is also known as this syndrome (H20 C90 P673)

Answer 15

Isaac syndrome

Question 16

Most common tumor associated with paraneoplastic neuropathy (H20 C90 P674)

Answer 16

SCLC