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SuprIM > 345 Urticaria, Angioedema, and Allergic Rhinitis > Flashcards

345 Urticaria, Angioedema, and Allergic Rhinitis Flashcards

1
Q

The binding of IgE to human mast cells and basophils is termed: (H20 C345 P2498)

A

Sensitization

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2
Q

The predominant mast cell prostanoid (H20 C345 P2499)

A

Prostaglandin D2

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3
Q

Most potent known bronchoconstrictor (H20 C345 P2499)

A

Leukotriene D4

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4
Q

Levels of this enzyme are inversely related to the severity of anaphylaxis (H20 C345 P2499)

A

PAF acetyl hydrolase

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5
Q

Receptor for stem cell factor (H20 C345 P2499)

A

c-kit

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6
Q

Key effector cells in allergic rhinitis and asthma (H20 C345 P2498)

A

Mast cells

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7
Q

Lipid mediator of neutrophil chemotaxis (H20 C345 P2500)

A

Leukotriene B4

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8
Q

Antigen-presenting cells of monocytic lineage that processes allergens (H20 C345 P2500)

A

Dendritic cells

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9
Q

Level of skin involved in urticaria (H20 C345 P2500)

A

Superficial dermis

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10
Q

Duration of acute urticaria/angioedema (H20 C345 P2500)

A

<6 weeks

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11
Q

Most common age group for chronic urticaria/angioedema (H20 C345 P2500)

A

3rd to 5th decade

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12
Q

Peak prevalence of dermatographism (H20 C345 P2501)

A

2nd-3rd decades

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13
Q

Distinctive size of wheals in cholinergic urticaria (H20 C345 P2501)

A

1-2 mm

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14
Q

Physical urticaria that often accompanies chronic idiopathic urticaria (H20 C345 P2501)

A

Pressure urticaria

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15
Q

Exercise-induced anaphylaxis is associated with the presence of IgE specific for this component of wheat (H20 C345 P2501)

A

α-5 gliadin

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16
Q

Most common sites for angioedema (H20 C345 P2501)

A

Periorbital, perioral

17
Q

Hereditary angioedema is caused by a mutation in this gene (H20 C345 P2502)

A

SERPING1

18
Q

Indication for biopsy of urticarial lesion (H20 C345 P2502)

A

Lasts longer than 36 h, result in scarring, painful and not pruritic

19
Q

Chronic angioedema with urticaria warrants assessment of: (H20 C345 P2502)

A

Complement levels

20
Q

Concomitant flushing and hyperpigmented papules that urticate with stroking in the absence of angioedema raise the question of: (H20 C345 P2502)

A

Mastocytosis

21
Q

Gene mutation involved in type 3 HAE (H20 C345 P2502)

A

Factor XII

22
Q

Add-on therapy for chronic idiopathic urticaria that is severe and poorly responsive to other therapies or when glucocorticoids are a requirement (H20 C345 P2502)

A

Cyclosporine

23
Q

Bradykinin 2 receptor agonist used to treat acute attacks of HAE (H20 C345 P2502)

A

Icatibant

24
Q

Kallikrein inhibitor used for treatment of acute attacks of HAE (H20 C345 P2502)

A

Ecallantide

25
Q

Preoperative prophylaxis for HAE (H20 C345 P2502)

A

Ɛ-aminocaproic acid

26
Q

Age group of peak prevalence of allergic rhinitis (H20 C345 P2502)

A

5th decade

27
Q

Characterized by nasal obstruction, anosmia, chronic sinusitis, prominent eosinophilic nasal discharge in the absence of allergen sensitization (H20 C345 P2503)

A

Perennial nonallergic rhinitis with eosinophilia syndrome

28
Q

Aside from pregnancy, what endocrinologic abnormality must be ruled out in the workup of allergic rhinitis (H20 C345 P2503)

A

Hypothyroidism

29
Q

Symptom of allergic rhinitis that is NOT relieved by antihistamines (H20 C345 P2505)

A

Nasal congestion

30
Q

Most potent drugs available for the relief of established rhinitis (H20 C345 P2505)

A

Intranasal high-potency glucocorticoids

31
Q

Most frequent side effect of intranasal high-potency glucocorticoids (H20 C345 P2505)

A

Local irritation

32
Q

Adverse effect of azelastine nasal spray (H20 C345 P2505)

A

Dysgeusia

33
Q

Mechanism of action of cromolyn sodium (H20 C345 P2505)

A

Inhibits mast cell degranulation

34
Q

Add-on therapy for persistent rhinorrhea in severe rhinitis (H20 C345 P2505)

A

Topical ipratropium

SuprIM (31 decks)

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