345 Urticaria, Angioedema, and Allergic Rhinitis

Question 1

The binding of IgE to human mast cells and basophils is termed: (H20 C345 P2498)

Answer 1

Sensitization

Question 2

The predominant mast cell prostanoid (H20 C345 P2499)

Answer 2

Prostaglandin D2

Question 3

Most potent known bronchoconstrictor (H20 C345 P2499)

Answer 3

Leukotriene D4

Question 4

Levels of this enzyme are inversely related to the severity of anaphylaxis (H20 C345 P2499)

Answer 4

PAF acetyl hydrolase

Question 5

Receptor for stem cell factor (H20 C345 P2499)

Answer 5

c-kit

Question 6

Key effector cells in allergic rhinitis and asthma (H20 C345 P2498)

Answer 6

Mast cells

Question 7

Lipid mediator of neutrophil chemotaxis (H20 C345 P2500)

Answer 7

Leukotriene B4

Question 8

Antigen-presenting cells of monocytic lineage that processes allergens (H20 C345 P2500)

Answer 8

Dendritic cells

Question 9

Level of skin involved in urticaria (H20 C345 P2500)

Answer 9

Superficial dermis

Question 10

Duration of acute urticaria/angioedema (H20 C345 P2500)

Answer 10

<6 weeks

Question 11

Most common age group for chronic urticaria/angioedema (H20 C345 P2500)

Answer 11

3rd to 5th decade

Question 12

Peak prevalence of dermatographism (H20 C345 P2501)

Answer 12

2nd-3rd decades

Question 13

Distinctive size of wheals in cholinergic urticaria (H20 C345 P2501)

Answer 13

1-2 mm

Question 14

Physical urticaria that often accompanies chronic idiopathic urticaria (H20 C345 P2501)

Answer 14

Pressure urticaria

Question 15

Exercise-induced anaphylaxis is associated with the presence of IgE specific for this component of wheat (H20 C345 P2501)

Answer 15

α-5 gliadin

Question 16

Most common sites for angioedema (H20 C345 P2501)

Answer 16

Periorbital, perioral

Question 17

Hereditary angioedema is caused by a mutation in this gene (H20 C345 P2502)

Answer 17

SERPING1

Question 18

Indication for biopsy of urticarial lesion (H20 C345 P2502)

Answer 18

Lasts longer than 36 h, result in scarring, painful and not pruritic

Question 19

Chronic angioedema with urticaria warrants assessment of: (H20 C345 P2502)

Answer 19

Complement levels

Question 20

Concomitant flushing and hyperpigmented papules that urticate with stroking in the absence of angioedema raise the question of: (H20 C345 P2502)

Answer 20

Mastocytosis

Question 21

Gene mutation involved in type 3 HAE (H20 C345 P2502)

Answer 21

Factor XII

Question 22

Add-on therapy for chronic idiopathic urticaria that is severe and poorly responsive to other therapies or when glucocorticoids are a requirement (H20 C345 P2502)

Answer 22

Cyclosporine

Question 23

Bradykinin 2 receptor agonist used to treat acute attacks of HAE (H20 C345 P2502)

Answer 23

Icatibant

Question 24

Kallikrein inhibitor used for treatment of acute attacks of HAE (H20 C345 P2502)

Answer 24

Ecallantide

Question 25

Preoperative prophylaxis for HAE (H20 C345 P2502)

Answer 25

Ɛ-aminocaproic acid

Question 26

Age group of peak prevalence of allergic rhinitis (H20 C345 P2502)

Answer 26

5th decade

Question 27

Characterized by nasal obstruction, anosmia, chronic sinusitis, prominent eosinophilic nasal discharge in the absence of allergen sensitization (H20 C345 P2503)

Answer 27

Perennial nonallergic rhinitis with eosinophilia syndrome

Question 28

Aside from pregnancy, what endocrinologic abnormality must be ruled out in the workup of allergic rhinitis (H20 C345 P2503)

Answer 28

Hypothyroidism

Question 29

Symptom of allergic rhinitis that is NOT relieved by antihistamines (H20 C345 P2505)

Answer 29

Nasal congestion

Question 30

Most potent drugs available for the relief of established rhinitis (H20 C345 P2505)

Answer 30

Intranasal high-potency glucocorticoids

Question 31

Most frequent side effect of intranasal high-potency glucocorticoids (H20 C345 P2505)

Answer 31

Local irritation

Question 32

Adverse effect of azelastine nasal spray (H20 C345 P2505)

Answer 32

Dysgeusia

Question 33

Mechanism of action of cromolyn sodium (H20 C345 P2505)

Answer 33

Inhibits mast cell degranulation

Question 34

Add-on therapy for persistent rhinorrhea in severe rhinitis (H20 C345 P2505)

Answer 34

Topical ipratropium