4: CT Diseases Flashcards
other name for cANCA and pANCA
cANCA = PR3-ANCA pANCA = MPO-ANCA
pericarditis presentation
substernal constant CP thats worse with cough, deep inspiration, supine; better with sitting up/leaning forward
pericarditis on ECG
diffuse ST elevation
why are SLE pts at higher risk of MI?
accelerated atherosclerosis
mortality in SLE during early vs later years
early: infections w opportunistic infection, kidney or CNS disease
late: accelerated atherosclerosis, MI, thromboembolic events
explain lupus anticoagulant (LA): in vivo vs in vitro
In vivo: procoagulant
in vitro: anti-coagulant - prolongs PTT
examples of some meds that can cause DIL - drug-induced lupus
procainamide, hydralazine, isoniazid, methyldopa, lithium, phenytoin, nitrofurantoin, sulfasalazine, HCTZ, simvastatin
DDx of discoid lupus (what it looks like)
tinea (ringworm), psoriasis, morphea (localized scleroderma)
first symptoms of Scleroderma in white vs black pts
white: raynaud’s
black: pigmentation changes
primary cause of morbidity and mortality in systemic sclerosis
pulmonary sx
ILD: interstitial lung disease presentation
chronic dry cough, dyspnea, “velcro” like crackles/rales
how to Dx interstitial lung disease
PFT
PAH: pulmonary artery HTN presentation
exertional dyspnea, syncope, angina, R heart failure, increased bronchoalveolar carcinoma
how to Dx PAH (pulmonary artery hypertension)
right heart cath
renal crisis presentation**
abrupt onset: malignant HTN, hemolytic anemia, progressive renal insufficiency
what treatment can induce renal crisis in pts with systemic sclerosis?***
high dose glucocorticoids
when would you bx a parotid gland in sjogren’s?
pts with atypical presentation to r/o cancer
treatment for sjogrens
treat sicca symptoms symptomatically, glucocorticoids for extraglandular manifestations
Gottron’s papules
raised violaceous lesions on dorsa of DIP, PIP, and MCP
heliotrope rash
periorbital edema, purple red discoloration
