1: Cholinergic Drugs

Question 1

Parasymp neurotransmitters and receptors

Answer 1

Nt: ACh
Receps: nicotinic + muscarinic

Question 2

Sympathetic neurotransmitters and receptors

Answer 2

Nts: norep, Epi
Receptors: a, B

Question 3

What muscarinic receptor is dominant in most organs?

Answer 3

M3

Question 4

What muscarinic receptor is most dominant in the heart?

Answer 4

M2

Question 5

Accommodative esotropia

Answer 5

Misalignment of the eyes caused by hypermetropic accommodative error

Question 6

What can cause anti cholinergic poisoning?

Answer 6

Atropine, anti-histamines, TCA’s, sleep aids, cold preparations

Question 7

Symptoms of anti-cholinergic poisoning

Answer 7

Cutaneous vasodilation, anhydrosis, anhydrotic hyperthermia, non-reactive mydriasis, delirium, hallucinations, reduction in desire to urinate

Question 8

AChE inhibitor toxicity symptoms

Answer 8

SLUDGE symptoms, effects on NMJ

Question 9

Cholinergic poisoning: what causes it

Answer 9

Insecticides, wild mushrooms, chemical warfare nerve gas -> medical emergency

Question 10

Classic saying for anticholinergic adverse effects when in high systemic concentration

Answer 10

Dry as a bone, blind as a bat, red as a beet, mad as a hatter, hot as a hare

Question 11

How to treat high systemic concentrations of anticholinergics

Answer 11

AChE inhibitors or symptomatically