17: Drugs for HTN

Question 1

two reasons you see increased TPR in chronic hypertension

Answer 1

1. follows an initial increased in CO

2. is the initiating event in chronic HTN

Question 2

three subcategories of primary HTN based on renin and which is the most common

Answer 2

Low renin, high renin, normal renin (most common)

Question 3

example causes of secondary HTN

Answer 3

renal/renovascular disease, primary aldosteronism, OPA, drugs/alcohol, pheochromocytoma, Cushing, hypo/hyperthyroid

Question 4

meds/substances that can raise BP

Answer 4

1. alcohol, caffeine, herbal supplements
2. amphetamines, recreational drugs
3. antidepressants, antipsychotics
4. decongestants, oral contraceptives, NSAIDs

Question 5

three functions of angiotensin II

Answer 5

1. vasoconstriction
2. increases ECF (by stimulating thirst, aldosterone, and ADH)
3. contributes to CV remodeling

Question 6

GFR falls when using ACEi. what does that mean for serum Creatinine?

Answer 6

it increases

Question 7

what drug class is known for causing angioedema?

Answer 7

ACEi

Question 8

effect of decreased angiotensin II on pts with renal stenosis vs DM pts

Answer 8

1. renal stenosis -> renal failure

2. DM -> preserves renal fx

Question 9

what happens if you suddenly stop a BB

Answer 9

excess cardiac stimulation -> tachycardia, rebound HTN, angina, MI, arrythmias

Question 10

what happens if you suddenly stop an a2-agonist

Answer 10

releases CNS brake on symp tone -> excess sympathetics -> rebound HTN

Question 11

syndromes associated with renovascular hypertension

Answer 11

v early or v late onset HTN, deterioration of renal fx, ARF during tx of HTN, flash pulmonary edema, progressive renal failure, refractory CHF

Question 12

Metabolic syndrome: 3/5 of the following…

Answer 12

1. abdominal obesity
2. triglycerides >150
3. HDL <50
4. BP >130/85
5. fasting plasma glucose >100