10: Drugs for ACS, Stable Angina

Question 1

likely cuase of vasospastic angina

Answer 1

genetic

Question 2

major problem in angina

Answer 2

imbalance between O2 demand and supply

Question 3

two approaches to treating angina

Answer 3

1. decrease cardiac work

2. increase blood flow through coronary arteries

Question 4

vasculature that is most to least sensitive to nitrates

Answer 4

veins -> large A’s -> small A’s

Question 5

how do drugs for erectile dysfunction work?

Answer 5

inhibit cGMP-phosphodiesterase5 -> increases cGMP -> smooth muscle relaxation

Question 6

three drugs used to treat ED

Answer 6

sildenafil, vardenafil, tadalafil

Question 7

why is it dangerous to take ED meds + nitrates

Answer 7

severe increase in cGMP -> dramatic drop in BP -> can cause MI

Question 8

functions of the heart of cardioactive vs non-cardioactive CCBs

Answer 8

1. cardioactive: vasodilation, decrease contractility, decrease automaticity, decrease AV node conduction
2. non-cardioactive: vasodilation

Question 9

composition of red vs white thrombus

Answer 9

red: fibrin + trapped RBCs
white: platelets

Question 10

where do red vs white thrombi form?

Answer 10

red: low-pressure evins, heart
white: high-pressure arteries

Question 11

pathologic conditions associated with white vs red thrombi

Answer 11

white: local ischemia
red: pain, severe swelling, embolism

Question 12

what ligands bind to platelet glycoprotein IIb/IIIa?

Answer 12

fibrinogen, fibronectin, vitronectin, vWF