3.2.2 Muscle Pathology I Flashcards
What are the characteristics of Dermatomyositis?
Proximal weakness
Rash - over 90% of the time
Complement deposition in capillaries
PERIVASCULAR INFLAMMATION - PERIMYSIUM
Associated with cancer - must screen individuals for cancers
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/326/865/a_image_thumb.png?1502308602)
What are some of the clinical features of the muscular dystrophy diseases?
Pelvic girdle weakness
Pseudohypertrophy of calf muscles
Initial CK increase and later decrease.
What determines whether a muscle cell will be a type 1 or type 2 muscle fiber?
The motor neuron
What is this an image of?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/326/817/q_image_thumb.png?1502308517)
Neurogenic atrophy
Many nuclear clumps (end-stage fibers) seen as well as some endomysial fibrous tissue increase.
These are diseases like - ALS, vasculitis, trauma, nerve compression.
What is this an image of?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/327/169/q_image_thumb.png?1502309457)
Muscular dystrophy
Endomysial fibrosis, regeneration, sometimes lymphocytes, rounded fibers, hypertrophic and smaller fibers can be seen.
Compare the Type 1 and 2 muscle fiber :
Action
Strength
Lipids
Glycogen
Physiology
Color
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/326/681/a_image_thumb.png?1502308280)
What is this an image of?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/327/097/q_image_thumb.png?1502309284)
Inclusion body myositis with abnormal fiber with vacuoles
What are these images indicative of?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/326/913/q_image_thumb.png?1502308720)
Dermatomyositis
Facial rash and perivascular inflammation
What are the characteristics of Inclusion Body Myositis?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/327/043/a_image_thumb.png?1502309128)
What is this an image of?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/326/613/q_image_thumb.png?1502308044)
Skeletal muscle - note the abundance of fat
What are the characteristics of Polymyositis?
Proximal weakness w/o skin involvement
ENDOMYSIAL PROCESS
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/327/004/a_image_thumb.png?1502309033)
Describe the pathological findings of Inclusion Body Myositis.
Inflammation and fibrosis
Intracytoplasmic vacuoles surrounded by basophilic granules: RED ON TRICHROME = RIMMED VACUOLES
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/327/050/a_image_thumb.png?1502309212)
What is this an image of?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/326/729/q_image_thumb.png?1502308308)
Oil Red O stain for fat
What is this an image of?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/218/326/975/q_image_thumb.png?1502308930)
Dermatomyositis
Perifascicular pattern of injury