3.2.1 Soft Tissue Pathology II

Question 1

Regardless of subtype, 95% of karposi sarcoma patients have been infected with what?

Answer 1

HHV-8, also known as KSHV

Question 2

Same retroperitoneal mass. The bottom image is the mass cut open. What is the dianosis?

Answer 2

Leiomyosarcoma

Question 3

Answer 3

B. Breast cancer with radiation

Question 4

Answer 4

Question 5

Answer 5

Question 6

This histo is from the uterus. What is the condition?

Answer 6

Leiomyoma

Question 7

Histology: vascular channels lined with plump anaplastic endothelial cells.

Diagnosis?

Answer 7

Angiosarcoma

Question 8

Where are hemangiomas most commonly found?

Answer 8

superficial lesions (head, neck)

Internally (liver)

Question 9

Answer 9

Question 10

In which gender are leiomyosarcomas more common?

Answer 10

Women

Question 11

What is the black arrow pointing to? What is the red box showing?

Answer 11

Black arrow: leiomyoma

Red box: endometrial cavity compresseed by leiomyoma

Question 12

What is unique about the histology of synovial sarcoma?

Answer 12

Biphasic tumor w/ both epithelial and mesenchymal components

(even if the tumor may are monophasic - staining will show positivity for both epithelial and mesenchymal components)

Question 13

What is the term for capillary hemangioma that is found on the skin of newborns? (extremly common)

Answer 13

Juvenile

Question 14

Name this tumor

Answer 14

Undifferentiated pleomorphic sarcoma

Question 15

What genetic abnormality is associated with synovial sarcoma?

Answer 15

chromosomal translocation (x;18)

Question 16

Does having HHV-8 mean that a patient will automatically get Karposi Sarcoma?

Answer 16

No, HHV-8 is required for KS development, but tumor progression also requires a cofactor (like HIV)

Question 17

Histology: vascular channels lined w/ plump anaplastic endothelial cells.

What type of tumor?

Answer 17

Angiosarcoma

Question 18

What are some common sites for angiosarcoma? and possible predisposing factors for that site?

Answer 18

Skin

Soft tissue

Breast: previous radiation therapy

Liver: arsenic, thorotrast, polyvinyl chloride

Question 19

What age group is most commonly affected by angiosarcoma?

Answer 19

older adults

Question 20

Answer 20

Question 21

Id the type of hemangioma

Answer 21

A and B: capillary hemangioma

C: Cavernous hemangioma

D: pyogenic granuloma

Question 22

Karposi sarcoma is what type of sarcoma?

Answer 22

Vascular sarcoma

Question 23

What type of tumor?

Answer 23

Synovial sarcoma

Question 24

What are some of the histologic features of leiomyoma?

Answer 24

Intersecting spindle cells w/ blunt-ended elongated nuclei, minimal atypia, few mitosis

Question 25

Answer

Answer 25

Question 26

What are the three histologic stages of karposi sarcoma?

Answer 26

Patches, plaques, nodules

Question 27

Answer 27

Question 28

What type of vascular tumor? Where is it commonly found?

Answer 28

Cavernous hemangioma; larger, more frequently found in deep structures (liver)

Question 29

What type of vascular tumor?

(exophytic nodule, skin, giingiva or oral mucosa, often ulcerated with extensive inflammation)

Answer 29

Pyogenic granuloma (lobular capillary hemangioma)

Question 30

What is the diagnosis?

Answer 30

Kaposi sarcoma (pt probably has HHV-8)

Question 31

What is the characteristic cell of this entity?

Answer 31

Rhabdomyoblast (strap cell)

Question 32

What type of tumor?

Answer 32

Capillary hemangioma: closely packed aggregates of thin-walled capillaries

Question 33

Answer 33

Question 34

Where do leiomyosarcomas typically arise?

Answer 34

skin, deep soft tissue of the extremities and retroperitoneum

Question 35

Karposi sarcoma is the most common cancer associated with what condition?

Answer 35

AIDS

Question 36

What is the best diagnosis in this case?

Answer 36

Leiomyoma (fibroid) in the uterus

Leiomyomas have blunt-ended, elongated nuclei with minimal atypia, and few mitoses

Question 37

What type of benign tumor often arises in the uterus?

Answer 37

Leiomyoma (fibroid)

Question 38

What are the three different types of hemangioma?

Answer 38

Capillary hemangioma, cavernous hemangioma, pyogenic granuloma (lobular capillary hemangioma)

Question 39

What type of soft tissue tumor?

Answer 39

Synovial sarcoma