3/20 repro Flashcards
female: mature vs immature teratoma
- which one is malignant?
- which one more likely to have thyroid tissue?
- immature = malignant.
- in males, a mature teratoma can also be malignant.
- mature = thyroid tissue (struma ovarii)
granulosa cell tumor
-what can it secrete?
E & also P.
Call-Exner bodies
- what do they look like?
- what are they found in?
- resemble primordial follicles
- granulosa cell tumor
Psammoma bodies found in which ovarian neoplasm?
Serous cystadenocarcinoma
Pseudomyxoma peritonei = “jelly belly”
- what is it?
- seen in what ovarian tumor?
- intraperitoneal accumulation of mucinous material from ovarian or appendiceal tumor.
- Mucinous cystadenocarcinoma
Dysgerminoma
- appearance?
- markers?
- Sheets of uniform “fried egg” cells D.
- hCG, LDH = tumor markers.
Choriocarcinoma
- are villi present?
- presentation?
- where does it commonly spread?
- no villi present
- Presents with abnormal β-hCG, shortness of breath, hemoptysis.
- lungs
Choriocarcinoma: gestational v. spontaneous germ cell:
-which one responds well to chemo?
-gestational has good response to chemo.
Schiller-Duval bodies
- what do they look like?
- what disease they found in?
- resemble glomeruli
- yolk sac tumor
Yolk sac tumor
- tumor marker?
- most commonly found in who?
- AFP
- male infants
SCC of vagina
-usually secondary to what?
Cervical SCC
Lower 1/3 of vagina => which LNs?
-inguinal nodes
upper 2/3 of vagina => which LNs?
-iliac nodes
Adenosis
- what is it?
- what causes it?
- can lead to which cancer?
-During fetal development, the squamous cells from distal 1/3 vaginal canal extends and replaces columnar epithelium in rest of vaginal canal. If this
process is disrupted and columnar cells persist, called adenosis.
-Seen in association w/female fetuses exposed to DES (Diethylstilbestrol) drug in utero.
-Adenosis can lead to clear cell adenocarcinoma.
Adenosis
-what lead to which cancer?
-Adenosis can lead to clear cell adenocarcinoma.
Sarcoma botryoides
- benign or malignant?
- variant of what type of tumor?
-malignant
-rhabdomyosarcoma variant
-
Sarcoma botryoides
- who does it affect?
- marker?
- girls < 4yo
- spindle-shaped tumor cells that are desmin (+).
desmin
-what is it?
IF present in muscle cells.
myogenin
-what is it?
Txn factor in immature skeletal muscle.
Breast: is the terminal duct proximal or distal to lobules?
proximal.
- attached to lobules.
*terminal makes it sound like its distal.
Fibroadenoma
-hormone sensitive?
- yes
- bigger during pregnancy or luteal phase.
Fibroadenoma
- associated w/usage of what?
- pre or post-menopausal?
- cyclosporine A (immunosuppressant) usage.
- pre-menopausal
endodermal sinus tumor
-aka?
yolk sac tumor
Why do breasts grow during pregnancy?
Breast tissue responds to E & P by growing.