29 Respiratory viruses

Question 0

Flu treatment

Answer 0

Attenuated live intranasal virus
Trivalent formalin vaccines

Antivirals

• amantadine and ramantadine- blocks m2 uncoating (easy resistance)
• Zanamavir and oseltamivir (block neuuraminidase and prevent release

Question 1

Influenza

Answer 1

16HA, 9NA
Distruction of respiratory epithelium by 3 days post infection
^ succeptability to 2ndary bacterial infections (Strep pneumoniae, staph aureus, haemophilus).
*Rare complications like myostis/cardiac- guianbarre, encephalitis, reyes

Question 2

Rhinovirus (PICORNA)

Answer 2

Common cold -150 serotypes
Mild and self limiting
Temp sensitive 33-37
fomite and secretion transmission
VP1 receptor uncoats (new drugs might block this)

Question 3

Enteroviruses(Picorna)

Answer 3

Naked + ssRNA
polio, coxsackie, echovvirus
respiratory infections
undifferentiated fevers

No treatments

Question 4

Coronavirus

Answer 4

Common cold
Enveloped + RNA
Epithelial URIs 
no vaccines 
SARS and MERS (not highly contageous)

Question 5

Parainfluenza virus

Answer 5

- ss RNA Naked
Late fall and winter
nosocomial
CROUP- in types 1 and 2
Type 3 - RSV like causing infant bronchiolitis

Question 6

RSV

Answer 6

- SS enveloped RNA
Respiratory infection only- no viremia
*Syncitia formed by multinucleated giant cells- lots of inflammatory cytokines
Winter prevalence
NO IMMUNOLOGIC PROTECTION

Supportive care
Immunocompromised or premature infants:
-aerolosized Ribovirin, sometimes anti RSV fusion protein antibodies

Question 7

Metapneumovirus

Answer 7

• SS enveloped

RSV like- but milder

Question 8

Hendra and Nipahvirus

Answer 8

-SS enveloped

High mortality

Question 9

Adenovirus

Answer 9

DS DNA Naked

Flu-like symptoms
pneumonia
Pharyngocunjunctival fever

WIDE SPECTRUM OFD DISEASE- can cause hemorrhagic cystitis
Vaccine for military only

Question 10

Measels

Answer 10

paramyxovvirus

Maculopapular rash
cough Conjunctivits, cold, croup, pneumonia - largest cause of childhood death with pneumonia.