25 Lung tumors Flashcards
Other factors causing Bronchogenic carcinoma
Air pollution-
- Radon exposure - indoor and in miners
Bronchogenic Carcinoma industrial hazards
Radiation - i.e. atomic bomb survvivors
Uranium miners
Asbestosis
Genes associated with Bronchogenic Carcinoma
Oncogenes- Cmyc(small cell carcinoma), (adenocarcinoma) —> Kras, EGFR, EML4-ALK
Tumor Supressor- p5, RB, short arm of chroomosome 3
Benzopyrene mech
Causes damager to p53 gene
Bronchogenic carcinoma etiology
“Scar cancer” ?? - occurs in vicinity of scarring
usually adenocarcinoma
May actually be that scar is response not cause of tumor
Bronchogenic carcinoma epidemiology
- present in 50s y.o.
- 7 months of symptoms usually- cough(70%), weight loss(40%), chest pain(40%), dyspnea (20%)
- increased sputum production (can get some malignant cells in sputum)
- frequently diagnosed 2/2 mets
Bronchogenic carrcinoma classifications
Small cell carcinoma -oat cell- lymphocyte like -intermediate cells - polygonal -combined - usually woth squamous Non small cell carcinoma -squamous cell- epidermoid carcinoma ***COMMON**** -adenocarcinoma ***COMMON**** *glandula with mucin, papulllar, solid, bronchioalveolar -Large cell carcinoma -Adenosquamous carcinoma
Other syndromes assocaited with lung tumors
Pneumonia/abscess/lobar collapes Lipid pneumonia Pleural eddusion hoarsness dysphagia rib distruction SVC syndrom/horners - pancoast tumor ***
Pancoast tumor
Tumor at apex of lung
- involvement of superior vena cava
- involvement of superior cervical ganglion- horners
Ipsilateral ptosis, myosis, anhydrosis
Chemo response in bronchogenic carcinoma
Non small cell carcinoma- surgery may be an option- can remove lower stage tumors
Small cell carcinomas treated with chemo and radiation
Bronchogenic carcinoma treatment advances
- Mutation specific: EGFR- treat with tyrosine kinase inhibitor, Kras, and EML4-ALK mutations (ADENOCARCINOMAS
- VEGF antibody- Bevacizumab- not for squamous cell carcinoma (hemmorrhhhage)
- Premetrexed- active in non squamous cell carcinoma
Smoking and bronchogenic carcinomas
Smokers 10x greater risk
Heavier smokers 20x
STOPPING FOR 10 YEARS RETURNS TO BASELINE
Small cell carcinoma
20-25% bronchogenic carcinomas 100% SMOKERS WORSTPROGNOSIS Endobronchial growth with small polyps neuroendicrine granules usually already advanced stage do respond to chemo- but its usually too late
Small cell histo
GROWS AROUND BRONCHIOLES
Small round blue cells like lymphocytes
Crush artifact
extensive necrosis
Non-Small Cell bronchogenic carcinomas
Squamous Adeno -Bronchioloalveolar Large cell Adenosquamous
***May be able to treat with surgery if caught early