25 Lung tumors Flashcards

0
Q

Other factors causing Bronchogenic carcinoma

A

Air pollution-

- Radon exposure - indoor and in miners

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1
Q

Bronchogenic Carcinoma industrial hazards

A

Radiation - i.e. atomic bomb survvivors
Uranium miners
Asbestosis

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2
Q

Genes associated with Bronchogenic Carcinoma

A

Oncogenes- Cmyc(small cell carcinoma), (adenocarcinoma) —> Kras, EGFR, EML4-ALK

Tumor Supressor- p5, RB, short arm of chroomosome 3

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3
Q

Benzopyrene mech

A

Causes damager to p53 gene

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4
Q

Bronchogenic carcinoma etiology

A

“Scar cancer” ?? - occurs in vicinity of scarring
usually adenocarcinoma
May actually be that scar is response not cause of tumor

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5
Q

Bronchogenic carcinoma epidemiology

A
  • present in 50s y.o.
  • 7 months of symptoms usually- cough(70%), weight loss(40%), chest pain(40%), dyspnea (20%)
  • increased sputum production (can get some malignant cells in sputum)
  • frequently diagnosed 2/2 mets
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6
Q

Bronchogenic carrcinoma classifications

A
Small cell carcinoma
-oat cell- lymphocyte like
-intermediate cells - polygonal
-combined - usually woth squamous
Non small cell carcinoma
-squamous cell- epidermoid carcinoma ***COMMON****
-adenocarcinoma ***COMMON****
    *glandula with mucin, papulllar, solid, bronchioalveolar
-Large cell carcinoma
-Adenosquamous carcinoma
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7
Q

Other syndromes assocaited with lung tumors

A
Pneumonia/abscess/lobar collapes
Lipid pneumonia
Pleural eddusion
hoarsness
dysphagia
rib distruction SVC syndrom/horners - pancoast tumor
***
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8
Q

Pancoast tumor

A

Tumor at apex of lung
- involvement of superior vena cava
- involvement of superior cervical ganglion- horners
Ipsilateral ptosis, myosis, anhydrosis

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9
Q

Chemo response in bronchogenic carcinoma

A

Non small cell carcinoma- surgery may be an option- can remove lower stage tumors

Small cell carcinomas treated with chemo and radiation

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10
Q

Bronchogenic carcinoma treatment advances

A
  • Mutation specific: EGFR- treat with tyrosine kinase inhibitor, Kras, and EML4-ALK mutations (ADENOCARCINOMAS
  • VEGF antibody- Bevacizumab- not for squamous cell carcinoma (hemmorrhhhage)
  • Premetrexed- active in non squamous cell carcinoma
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11
Q

Smoking and bronchogenic carcinomas

A

Smokers 10x greater risk
Heavier smokers 20x
STOPPING FOR 10 YEARS RETURNS TO BASELINE

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12
Q

Small cell carcinoma

A
20-25% bronchogenic carcinomas
100% SMOKERS
WORSTPROGNOSIS
Endobronchial growth with small polyps
neuroendicrine granules
usually already advanced stage
do respond to chemo- but its usually too late
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13
Q

Small cell histo

A

GROWS AROUND BRONCHIOLES

Small round blue cells like lymphocytes
Crush artifact
extensive necrosis

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14
Q

Non-Small Cell bronchogenic carcinomas

A
Squamous
Adeno
-Bronchioloalveolar
Large cell
Adenosquamous

***May be able to treat with surgery if caught early

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15
Q

Squamous cell carcinomea

A

23-40% of bronchogenic carcinoma
Most common in males with cigarette smoking
Cavitary Necrosis
Endobronchial in large bronchi (main or lobar)
Histo- Keratin formation- SQUAMOUS PEARLS intracellular bridges

16
Q

Adenocarcinoma

A
25-45% bronchogenic carcinomas
Most common in women and nonsmokers
MOST COMMON IN USA
Usually peripheral
Slow growing- asymptomatic, usually metastasize before diagnosis
17
Q

Adenocarcinoma histology

A
Glandular
-May be glandular with epithelioid lining
Solid
-large sheets of cells - no glands
Papillary
-fingerlike projections into alveoli
BRONCHIOLOALVEOLAR
-follows alvoelar septa "Lepidic"
18
Q

Bronchioloalveolar

A

1-9% all lung cancers
subset of adenocarcinoma
Goss histology- FOLLOWS ARCHITECTURE OF LUNG
*Nonmucinous(clara cells and type II pneumocytes) 66% of cases
-Nodular (single or multifocal)
-No mucin vacuoles lining epithelium on LM
*Mucinous (tall columnar cells) 33% of cases
-Diffuse infiltrates(pneumonia like and slimy)- AGRESSIVE
- Mucin vacuoles on columnar cells in epithelium

19
Q

Large cell carcinoma

A

10-15% of bronchogenic carcinoma
pleomorphic large cells with giant cells- some semblance of glandular or squamous
Poor prognosis (6%) 5 year survival

  • Giant cell carcinoma
    • most malignant
    • peripheral
    • <10 month surival
20
Q

Adenosquamous carcinoma

A

1-3% of bronchogenic carcinomas

Peripheral scarred tumor with adeno and squamous together

21
Q

Bronchogenic CA spread

A
Hilar lymph nodes
Adrenals
Liver
Brain
Bone
22
Q

TNM staging

A

T 1-4,
- 1 no bronchus or pleural,
- 2 involving bronch 2cm from crania
- 3 involves chest walls or other anatomy
- 4 involves mediastinum, heart,other important anatomy may be with malignant PE
N 0-3
- 0 no nodes
- 1 hilar or peribronchial nodes
- 2 mediastinal or subcarinal ipsilateral
- 3 contralateral spread or supraclavicular
M 0-1
- 0 no mets
- 1 mets

23
Q

Cancer class staging

A

Stage I- no nodes T1 or 2
Stage II - nodes T1or2, no nodes T3
Stage III - T3 with 1 node, or any with nodes 2 or above
Stage IV- Metastatic

24
Q

Paraneoplastic syndromes

A

Symptom complexes in CA patients not directly due to cancer 1-10% cancer patients

  • cushings (ACTH)
  • Hyponatremia (ADH)
  • Carcinoid (serotonin)
  • Hypercalcemia(PTH)
  • Myasthenic syndrome
25
Q

Carcinoid tumors

A
1-5% lung tumors
Younger patients
Usually low grade
usually well circumscribed fleshy mass within bronchus
GOOD PROGNOSIS. 
RARE mets
Surgical excision
26
Q

Carcinoid histology

A

Salt and pepper chromatin
monomorphic cells
no mitoses
round to ovoid