27 Flashcards
- Fibrinogen group consists of
A. factors II, VII, IX, and X
B. factors I, V, VIII, and XIII
C. factors XI, XII, prekallikrein, and high–molecular weight kininogen
B. factors I, V, VIII, and XIII
- Prothrombin group consists of
A. factors II, VII, IX, and X
B. factors I, V, VIII, and XIII
C. factors XI, XII, prekallikrein, and high–molecular weight kininogen
A. factors II, VII, IX, and X
- Contact group consists of
A. factors II, VII, IX, and X
B. factors I, V, VIII, and XIII
C. factors XI, XII, prekallikrein, and high–molecular weight kininogen
C. factors XI, XII, prekallikrein, and high–molecular weight kininogen
- The fibrinogen group of coagulation factors is
A. known to increase during pregnancy
B. known to increase in conditions of inflammation
C. known to increase subsequent to the use of oral contraceptives
D. all of the above
D. all of the above
- The prothrombin group of coagulation factors is
A. dependent on vitamin K for production
B. considered to be stable
C. well preserved in stored plasma
D. all of the above
D. all of the above
- Warfarin acts by
A. neutralizing the effects of thrombin
B. interfering with fibrin monomer formation
C. acting as a vitamin K antagonist
D. inducing hypercoagulation
C. acting as a vitamin K antagonist
- Warfarin drugs interfere with the normal synthesis of factor(s)
A. II
B. VII
C. X
D. all of the above
A. II
- Vitamin-K dependent coagulation factors include factor(s)
A. II
B. V
C. VIII
D. XIII
A. II
- Symbolic designation for thrombin is
A. III
B. XII
C. VIII
D. IIa
D. IIa
- Symbolic designation for tissue thromboplastin is
A. III
B. XII
C. VIII
D. IIa
A. III
- Symbolic designation for antihemophilic factor is
A. III
B. XII
C. VIII
D. IIa
C. VIII
- Symbolic designation for Hageman factor is
A. III
B. XII
C. VIII
D. IIa
B. XII
13 through 16. Arrange the four stages of coagulation in their proper sequence.
A. Fibrinolysis
B. Formation of thrombin from prothrombin
C. Generation of plasma thromboplastin
D. Formation of fibrin from fibrinogen
- _______
- _______
- _______
- _______
- C. Generation of plasma thromboplastin
- B. Formation of thrombin from prothrombin
- D. Formation of fibrin from fibrinogen
- A. Fibrinolysis
- The extrinsic pathway of coagulation is triggered by the entry of _______ into the circulation.
A. membrane lipoproteins (phospholipoproteins)
B. tissue thromboplastin
C. Ca2+
D. factor VII
B. tissue thromboplastin
- The intrinsic pathway of coagulation begins with the activation of _______ in the early stage.
A. factor II
B. factor I
C. factor XII
D. factor V
C. factor XII
- The final common pathway of the intrinsic-extrinsic pathway is
A. factor X activation
B. factor II activation
C. factor I activation.
D. factor XIII activation.
A. factor X activation
- Prothrombin to thrombin conversion is accelerated by
A. a complex of activated factors IX and VII
B. factor V and ionized calcium
C. a complex of phospholipids and factor VII
D. a complex of activated factors X and V
B. factor V and ionized calcium
- Fibrinogen is converted to fibrin monomers by
A. prothrombin
B. thrombin
C. calcium ions
D. factor XIIIa
B. thrombin
- The inactive plasminogen is activated to _______ by proteolytic enzymes.
A. prothrombin
B. plasmin
C. plasma kallikrein
D. plasma thromboplastin antecedent
B. plasmin
Which of the following statements are true of the fibrinolytic system?
A. Plasmin digests fibrin and fibrinogen
B. The active enzyme of the system is plasmin
C. Inactive plasminogen circulates in the plasma until an injury occurs
D. All of the above
D. All of the above
If a pediatric preoperative patient has a family history of bleeding but has never had a bleeding episode herself, what test should be included in a coagulation profile in addition to the PT, APTT, and platelet count?
A. Lee-White clotting time
B. Clot retraction
C. Bleeding time
D. Fibrin split products
C. Bleeding time
A patient with a severe decrease in factor X activity would demonstrate normal
A. APTT
B. PT
C. thrombin time
D. bleeding time
D. bleeding time
- Neither the APTT nor the PT detects a deficiency of
A. platelet factor 3
B. factor VII
C. factor VIII
D. factor IX
A. platelet factor 3
- The function of thromboplastin in the prothrombin test is to provide _______ to the assay.
A. kaolin
B. fibrinogen
C. phospholipoprotein
D. thrombin
C. phospholipoprotein
- An abnormally prolonged APTT may indicate
A. a severe depletion of fibrinogen
B. the presence of a circulating anticoagulant
C. factor VIII deficiency
D. all of the above
D. all of the above
- If a child ingested rat poison, which of the following tests should be performed to test the effect of the poison on the child’s coagulation mechanism?
A. APTT
B. PT
C. Fibrinogen assay
D. Thrombin time
B. PT
Which of the following conditions can cause an increased thrombin time?
A. Fibrin split products
B. High concentrations of immunoglobulins
C. Heparin therapy
D. All of the above
D. All of the above
Heparin inhibits the clotting of blood by neutralizing the effect of
A. thrombin
B. calcium ions
C. platelets
D. factor VIII
A. thrombin
A patient has a prolonged APTT and a normal PT. The APTT is not corrected by factor VIII–deficient plasma but is corrected by factor IX–deficient plasma. In which factor does the patient appear to be deficient?
A. Factor II
B. Factor V
C. Factor VIII
D. Factor IX
C. Factor VIII
- The normal protective mechanisms against thrombosis include
A. the flow of blood
B. the action of antithrombin.
C. protein C and protein S
D. all of the above
D. all of the above
- If heparin therapy is initiated in a patient, a decreased anticoagulant response can be caused by decreased levels of
A. platelet factor 3
B. platelet factor 4
C. antithrombin
D. factor XIII
B. platelet factor 4
- Which of the following is (are) characteristic of protein C?
A. It is not vitamin K dependent.
B. It is formed in response to thrombin generation.
C. It inactivates factors Va and VIIIa.
D. Both B and C.
D. Both B and C.
- Which of the following characteristics is (are) true of protein S?
A. It is a cofactor of protein C.
B. It increases the rate of inactivation of factor Va.
C. It enhances the binding of activated protein C to phospholipids.
D. All of the above.
D. All of the above.
- Antithrombin is the principal physiological inhibitor of
A. thrombin
B. factor Xa
C. factor XIa
D. both A and B
A. thrombin
- Which of the following is not correct regarding cellular proteases?
A. They block the activation or action of plasmin.
B. They include alpha-2 inhibitor.
C. They rapidly neutralize the fibrinolytic properties of plasmin.
D. They participate in clot formation.
D. They participate in clot formation.
