21 Flashcards
- Which of the following are typical characteristics of an acute leukemia?
A. Replacement of normal marrow elements by leukocytic blasts and bleeding episodes
B. Blasts and immature leukocytes in the peripheral blood and anemia
C. Leukocytosis
D. All of the above
D. All of the above
- Myeloid and monocytic acute leukemias are classified as FAB
A. M1
B. M4
C. M5
D. L1
B. M4
- Monocytic acute leukemia is classified as FAB
A. M1
B. M4
C. M5
D. L1
C. M5
- Myeloid without maturation acute leukemias is classified as FAB
A. M1
B. M4
C. M5
D. L1
A. M1
- Lymphoblastic (one cell population) acute leukemias are classified as FAB
A. M1
B. M4
C. M5
D. L1
D. L1
- Characteristics of FAB M1 include
A. leukocytosis with maturation of the myeloid cell line in the peripheral blood
B. leukocytosis with maturation of the lymphocytic cell line in the peripheral blood
C. leukocytosis without maturation of the myeloid cell line in the peripheral blood
D. leukocytosis with many mature leukocytes in the peripheral blood
C. leukocytosis without maturation of the myeloid cell line in the peripheral blood
- The incidence of FAB M1 is
A. high in children younger than 18 months of age
B. high in children between 1.5 and 12 years of age
C. high in middle-aged adults
D. both A and C
D. both A and C
- A mixture of myeloid and monocytic blasts predominate in
A. FAB M2
B. FAB M3
C. FAB M4
D. FAB M6
C. FAB M4
- Blasts of the monocytic type predominate in
A. FAB M2
B. FAB M3
C. FAB M4
D. FAB M5
D. FAB M5
- Many coarsely granular promyelocytes with dumbbell-shaped or bilobed nuclei predominate in
A. FAB M2
B. FAB M3
C. FAB M4
D. FAB M6
B. FAB M3
- Myeloblasts, promyelocytes, and myelocytes predominate in
A. FAB M2
B. FAB M3
C. FAB M4
D. FAB M6
A. FAB M2
Which cytochemical stain will demonstrate lysosomal enzyme activity in primary azurophilic granules?
A. Prussian Blue
B. Sudan Black B
C. Periodic acid–Schiff (PAS)
D. Myeloperoxidase
D. Myeloperoxidase
Multinucleated (3–5) erythroid precursors are usually seen in
A. acute myeloblastic leukemia without maturation
B. chronic myeloid leukemia
C. myelofibrosis
D. acute lymphoblastic leukemia
A. acute myeloblastic leukemia without maturation
The M:E ratio in acute erythroid leukemia is usually
A. high
B. normal
C. variable
D. low
D. low
Auer rods are
A. an aggregation of lysosomes or primary granules
B. peroxidase negative
C. LAP positive
D. associated with lymphoblasts
A. an aggregation of lysosomes or primary granules
One cytochemical stain that can differentiate most cases of precursor lymphoblastic leukemia from other fomrs of leukemia is
A. peroxidase
B. alkaline phosphatase
C. nonspecific esterease
D. TdT terminal deoxynucleotidyla transferase
D. TdT terminal deoxynucleotidyla transferase
Which cellular series can be identified by a positive Sudan Black B reaction?
A. Lymphocytic
B. Monocytic
C. Myelocytic
D. Erythrocytic
C. Myelocytic
Which type of cell demonstrates the most intense peroxidase reaction?
A. neutrophil, expect blast forms
B. Basophil
C. Lymphocyte
D. Monocyte
A. neutrophil, expect blast forms
Which cytochemical stain is associated with selectively identifying lipoproteins in the cellular membranes of myelogenous cells and mitochrondria?
A. Sudan Black B
B. LAP
C. Nonspecific esterease
D. Acid phosphatase
A. Sudan Black B
Which cytochemical stain is associated with staining glycogen and related mucopolysaccharides?
A. Sudan Black B
B. LAP
C. Periodic acid Schiff stain (PAS)
D. Acid phosphatase
C. Periodic acid Schiff stain (PAS)
- Leukemia secondary to Burkitt’s lymphoma is classified as
A. FAB M1
B. FAB L1
C. FAB L2
D. FAB L3
D. FAB L3
- Childhood lymphoblastic leukemia is classified as
A. FAB M1
B. FAB L1
C. FAB L2
D. FAB L3
B. FAB L1
- Older children and adults are typically classified with
A. FAB M1
B. FAB L1
C. FAB L2
D. FAB L3
C. FAB L2
Chloromas are associated with
A. FAB M1
B. FAB M3
C. FAB M4
D. FAB M5
A. FAB M1
A common characteristic of ALL is
A. bone and joint pain
B. many blast cells with Auer rods
C. leukocytopenia
D. a leukemia of older persons
A. bone and joint pain
Specific nature B-cell surface marker(s) membrane is
A. CD 79a
B. CD19
C. CD 20
D. ALL OF THE ABOVE
B. CD19
Patients with AML have a good prognosis if
A. less than 45 years of age
B. Auer rods are present in blast cells
C. Ph chromosome
D. all of the above
A. less than 45 years of age
Which of the following classification systems delineates each subtype of acute leukemia on immunophenotyping and cytogenetic analysis as well as morphology?
A. REAL
B. WHO
C. FAB
D. EYE
B. WHO
A medical laboratory scientist is reviewing a patient’s peripheral blood smear and notices many eosinophils in addition to two different populations of blasts—myeloid and monocytic. Immunophenotyping revealed blasts were positive for CD14 and CD33. Which of the following cytogenetic abnormalities would be an expected finding with this picture?
A. t (9, 22) (q34; q11.2)
B. del (5q) (31)
C. 11q23
D. inv (16)9p13q22
D. inv (16)9p13q22
A 27-year-old woman presents with acute bleeding to the emergency department and is found to have a white count of 25.7
× 109L with pancytopenia: hematocrit 27%, platelet count 35 × 109/L, and absolute neutrophil count 0.8 × 109/L. She has a combination of 97% blasts and abnormal promyelocytes in her peripheral blood; some of these cells contain stacked Auer rods.
What form of leukemia does she most likely have?
A. acute myeloid with t (15; 17) (q22:q12)
B. chronic myeloid leukemia
C. acute monoblastic leukemia
D. acute myeloid with t (8; 21) (q33:q22)
A. acute myeloid with t (15; 17) (q22:q12)
A confirmed ALL patient was also positive for the Philadelphia chromosome. What conclusions can you make from this?
A. the patient has a better prognosis
B. the patient has a poorer prognosis
C. the patient’s treatment regimen is effective
D. the wrong patient was analyzed
B. the patient has a poorer prognosis
A diagnosis of an acute leukemia according to the World Health Organization is defined by:
A. a high WBC count
B. blasts in the peripheral blood
C. >20% non-erythroid blasts in the bone marrow
D. hepatosplenomegaly
C. >20% non-erythroid blasts in the bone marrow
An unknown blast is positive for CD34, CD19, CD10 (CALLA), CD22 and TdT. Using WHO guidelines, this immunophenotyping profile is consistent with which classification of ALL?
A. early pre-B cell
B. common ALL
C. pre-B cell ALL
D. T-cell ALL
B. common ALL
ALL Prognosis is NOT dependent on which of the following?
A. tumor burden
B. immunophenotype
C. genetic abnormalities
D. morphology of the blasts
D. morphology of the blasts
Patients with Down Syndrome are predisposed to developing ALL due to what genetic alteration?
A. Philadelphia chromosome
B. GATA1 mutation
C. deletion of 5q
D. no genetic alterations have been seen
B. GATA1 mutation
