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Turgeon 6th > 16 > Flashcards

16 Flashcards

1
Q
  1. Hemolytic disruption of the erythrocyte involves
    A. an alteration in the erythrocyte membrane
    B. a defect of the hemoglobin molecule
    C. an antibody coating the erythrocyte
    D. physical trauma
A

A. an alteration in the erythrocyte membrane

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2
Q
  1. Intravascular hemolysis is
    A. destruction of RBCs outside the circulatory blood
    B. destruction of RBCs within the circulatory blood
A

B. destruction of RBCs within the circulatory blood

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3
Q
  1. Extravascular hemolysis is
    A. destruction of RBCs outside the circulatory blood
    B. destruction of RBCs within the circulatory blood
A

A. destruction of RBCs outside the circulatory blood

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4
Q
  1. Which of the following tests is not useful in determining increased erythrocyte destruction?
    A. Reticulocyte count
    B. Total leukocyte count
    C. Serum haptoglobin
    D. Unconjugated bilirubin
A

B. Total leukocyte count

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5
Q
  1. G6PD deficiency is a disorder with a (an) __________.
    A. structural membrane defect
    B. erythrocytic enzyme defect
    C. defect of the hemoglobin molecule
    D. defect in heme synthesis
A

B. erythrocytic enzyme defect

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6
Q
  1. Hereditary spherocytosis is a disorder with a (an) __________.
    A. structural membrane defect
    B. erythrocytic enzyme defect
    C. defect of the hemoglobin molecule
    D. defect in heme synthesis
A

A. structural membrane defect

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7
Q
  1. Thalassemia is a disorder with a(an) __________.
    A. structural membrane defect
    B. erythrocytic enzyme defect
    C. defect of the hemoglobin molecule
    D. defect in heme synthesis
A

C. defect of the hemoglobin molecule

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8
Q
  1. Pyruvate kinase (PK) deficiency is a disorder with a (an) __________.
    A. structural membrane defect
    B. erythrocytic enzyme defect
    C. defect of the hemoglobin molecule
    D. defect in heme synthesis
A

B. erythrocytic enzyme defect

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9
Q
  1. Hereditary spherocytosis is
    A. an overabundance of oval-shaped red cells
    B. a permeability disorder
    C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
    D. seen in the genetic hemoglobin defect, thalassemia
A

C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent

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10
Q
  1. Hereditary elliptocytosis is
    A. an overabundance of oval-shaped red cells
    B. a permeability disorder
    C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
    D. seen in the genetic hemoglobin defect, thalassemia
A

A. an overabundance of oval-shaped red cells

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11
Q
  1. Hereditary pyropoikilocytosis (HPP) is
    A. an overabundance of oval-shaped red cells
    B. a permeability disorder
    C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
    D. a subgroup of common hereditary elliptocytosis
A

D. a subgroup of common hereditary elliptocytosis

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12
Q
  1. Hereditary stomatocytosis is

A. an overabundance of oval-shaped red cells
B. a permeability disorder
C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. seen in the genetic hemoglobin defect, thalassemia

A

D. seen in the genetic hemoglobin defect, thalassemia

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13
Q
  1. Hereditary xerocytosis is
    A. an overabundance of oval-shaped red cells
    B. a permeability disorder
    C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
    D. seen in the genetic hemoglobin defect, thalassemia
A

B. a permeability disorder

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14
Q
  1. Heinz bodies are associated with the congenital hemolytic anemia
    A. G6PD deficiency
    B. abetalipoproteinemia
    C. hereditary spherocytosis
    D. hemolytic anemias
A

A. G6PD deficiency

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15
Q
  1. A hemolytic crisis may be precipitated in 10% of American Black males suffering from G6PD deficiency by
    A. fava beans
    B. primaquine
    C. quinine
    D. quinidine
A

B. primaquine

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16
Q
  1. What is the most common glycolytic enzyme deficiency associated with the aerobic pathway of erythrocyte metabolism?
    A. Glucose-6-phosphate dehydrogenase (G6PD)
    B. Pyruvate kinase (PK)
    C. Methemoglobin reductase deficiency
    D. Hexokinase deficiency
A

A. Glucose-6-phosphate dehydrogenase (G6PD)

17
Q
  1. What is the most common glycolytic enzyme deficiency associated with the anaerobic pathway of erythrocyte metabolism?
    A. Glucose-6-phosphate dehydrogenase (G6PD)
    B. Pyruvate kinase (PK)
    C. Methemoglobin reductase deficiency
    D. Hexokinase deficiency
A

B. Pyruvate kinase (PK)

18
Q
  1. What laboratory assay would specifically indicate a deficiency of G6PD enzyme?
    A. Heinz bodies on peripheral blood smears
    B. Reticulocyte count
    C. Hemoglobin and hematocrit
    D. Osmotic fragility test
A

A. Heinz bodies on peripheral blood smears

19
Q
  1. What enzyme deficiency causes methemoglobinemia?
    A. Glucose-6-phosphate dehydrogenase (G6PD)
    B. Pyruvate kinase (PK)
    C. NADH-methemoglobin reductase
    D. Hexokinase deficiency
A

C. NADH-methemoglobin reductase

20
Q
  1. Acquired hemolytic anemia can be caused by
    A. chemicals or drugs
    B. infectious organisms
    C. antibody reactions
    D. all of the above
A

D. all of the above

21
Q

The infectious microorganism directly associated with hemolytic uremic syndrome is
A. Pasteurella tularensis
B. E. coli O157-H7
C. Staphylococcus aureus
D. Clostridium botulinum

A

B. E. coli O157-H7

22
Q

In warm-type autoimmune hemolytic anemia (AIHA)
A. IgM, usually anti-I, is present
B. Rh antibodies are the most frequent cause
C. IgM usually occurs in newborn infants
D. autoantibodies are present

A

B. Rh antibodies are the most frequent cause

23
Q

In cold-type AIHA
A. IgM, usually anti-I, is present
B. Rh antibodies are the most frequent cause
C. IgM usually occurs in newborn infants
D. autoantibodies are present

A

A. IgM, usually anti-I, is present

24
Q

In isoimmune hemolytic anemia

A. IgM, usually anti-I, is present
B. Rh antibodies are the most frequent cause
C. IgM usually occurs in newborn infants
D. autoantibodies are present

A

C. IgM usually occurs in newborn infants

25
Q
  1. The erythrocyte alteration characteristically associated with hemolytic anemias is
    A. hypochromia
    B. macrocytosis
    C. spherocytosis
    D. burr cells
A

C. spherocytosis

26
Q
  1. What laboratory procedures would reflect a typical hemolytic anemia?
    A. Increased osmotic fragility
    B. Increased total serum bilirubin
    C. Increased reticulocyte count, unless hematopoiesis is suppressed
    D. All of the above
A

D. All of the above

27
Q
  1. Which of the following is not associated with hemolytic anemia?
    A. Decreased hemoglobin and packed cell volume
    B. Increased reticulocyte count
    C. Increased serum haptoglobins
    D. Decreased erythrocyte survival
A

C. Increased serum haptoglobins

28
Q

Paroxysmal nocturnal hemoglobinuria exhibits sensitivity of one population of red blood cells to
A. warm antibodies
B. cold antibodies
C. complement
D. either A or B

A

C. complement

29
Q

Paroxysmal nocturnal hemoglobinuria episodes are usually associated with

A. cold temperatures
B. hot temperatures
C. sleep
D. certain foods or drugs

A

C. sleep

30
Q

The defect in PNH probably is a (an) __________ associated defect of the red cell membrane.
A. structural protein
B. hemoglobin
C. antibody
D. enzyme

A

A. structural protein

Turgeon 6th (32 decks)

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