16 Flashcards
(30 cards)
- Hemolytic disruption of the erythrocyte involves
A. an alteration in the erythrocyte membrane
B. a defect of the hemoglobin molecule
C. an antibody coating the erythrocyte
D. physical trauma
A. an alteration in the erythrocyte membrane
- Intravascular hemolysis is
A. destruction of RBCs outside the circulatory blood
B. destruction of RBCs within the circulatory blood
B. destruction of RBCs within the circulatory blood
- Extravascular hemolysis is
A. destruction of RBCs outside the circulatory blood
B. destruction of RBCs within the circulatory blood
A. destruction of RBCs outside the circulatory blood
- Which of the following tests is not useful in determining increased erythrocyte destruction?
A. Reticulocyte count
B. Total leukocyte count
C. Serum haptoglobin
D. Unconjugated bilirubin
B. Total leukocyte count
- G6PD deficiency is a disorder with a (an) __________.
A. structural membrane defect
B. erythrocytic enzyme defect
C. defect of the hemoglobin molecule
D. defect in heme synthesis
B. erythrocytic enzyme defect
- Hereditary spherocytosis is a disorder with a (an) __________.
A. structural membrane defect
B. erythrocytic enzyme defect
C. defect of the hemoglobin molecule
D. defect in heme synthesis
A. structural membrane defect
- Thalassemia is a disorder with a(an) __________.
A. structural membrane defect
B. erythrocytic enzyme defect
C. defect of the hemoglobin molecule
D. defect in heme synthesis
C. defect of the hemoglobin molecule
- Pyruvate kinase (PK) deficiency is a disorder with a (an) __________.
A. structural membrane defect
B. erythrocytic enzyme defect
C. defect of the hemoglobin molecule
D. defect in heme synthesis
B. erythrocytic enzyme defect
- Hereditary spherocytosis is
A. an overabundance of oval-shaped red cells
B. a permeability disorder
C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. seen in the genetic hemoglobin defect, thalassemia
C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
- Hereditary elliptocytosis is
A. an overabundance of oval-shaped red cells
B. a permeability disorder
C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. seen in the genetic hemoglobin defect, thalassemia
A. an overabundance of oval-shaped red cells
- Hereditary pyropoikilocytosis (HPP) is
A. an overabundance of oval-shaped red cells
B. a permeability disorder
C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. a subgroup of common hereditary elliptocytosis
D. a subgroup of common hereditary elliptocytosis
- Hereditary stomatocytosis is
A. an overabundance of oval-shaped red cells
B. a permeability disorder
C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. seen in the genetic hemoglobin defect, thalassemia
D. seen in the genetic hemoglobin defect, thalassemia
- Hereditary xerocytosis is
A. an overabundance of oval-shaped red cells
B. a permeability disorder
C. the most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. seen in the genetic hemoglobin defect, thalassemia
B. a permeability disorder
- Heinz bodies are associated with the congenital hemolytic anemia
A. G6PD deficiency
B. abetalipoproteinemia
C. hereditary spherocytosis
D. hemolytic anemias
A. G6PD deficiency
- A hemolytic crisis may be precipitated in 10% of American Black males suffering from G6PD deficiency by
A. fava beans
B. primaquine
C. quinine
D. quinidine
B. primaquine
- What is the most common glycolytic enzyme deficiency associated with the aerobic pathway of erythrocyte metabolism?
A. Glucose-6-phosphate dehydrogenase (G6PD)
B. Pyruvate kinase (PK)
C. Methemoglobin reductase deficiency
D. Hexokinase deficiency
A. Glucose-6-phosphate dehydrogenase (G6PD)
- What is the most common glycolytic enzyme deficiency associated with the anaerobic pathway of erythrocyte metabolism?
A. Glucose-6-phosphate dehydrogenase (G6PD)
B. Pyruvate kinase (PK)
C. Methemoglobin reductase deficiency
D. Hexokinase deficiency
B. Pyruvate kinase (PK)
- What laboratory assay would specifically indicate a deficiency of G6PD enzyme?
A. Heinz bodies on peripheral blood smears
B. Reticulocyte count
C. Hemoglobin and hematocrit
D. Osmotic fragility test
A. Heinz bodies on peripheral blood smears
- What enzyme deficiency causes methemoglobinemia?
A. Glucose-6-phosphate dehydrogenase (G6PD)
B. Pyruvate kinase (PK)
C. NADH-methemoglobin reductase
D. Hexokinase deficiency
C. NADH-methemoglobin reductase
- Acquired hemolytic anemia can be caused by
A. chemicals or drugs
B. infectious organisms
C. antibody reactions
D. all of the above
D. all of the above
The infectious microorganism directly associated with hemolytic uremic syndrome is
A. Pasteurella tularensis
B. E. coli O157-H7
C. Staphylococcus aureus
D. Clostridium botulinum
B. E. coli O157-H7
In warm-type autoimmune hemolytic anemia (AIHA)
A. IgM, usually anti-I, is present
B. Rh antibodies are the most frequent cause
C. IgM usually occurs in newborn infants
D. autoantibodies are present
B. Rh antibodies are the most frequent cause
In cold-type AIHA
A. IgM, usually anti-I, is present
B. Rh antibodies are the most frequent cause
C. IgM usually occurs in newborn infants
D. autoantibodies are present
A. IgM, usually anti-I, is present
In isoimmune hemolytic anemia
A. IgM, usually anti-I, is present
B. Rh antibodies are the most frequent cause
C. IgM usually occurs in newborn infants
D. autoantibodies are present
C. IgM usually occurs in newborn infants
