14 Flashcards
- Most operational iron in human beings is found in
A. the bone marrow
B. the liver
C. heme portion of hemoglobin and myoglobin
D. the free hemoglobin in the circulation
C. heme portion of hemoglobin and myoglobin
- The etiology of IDA is
A. nutritional deficiency
B. faulty iron absorption
C. excessive loss of iron
D. all of the above
D. all of the above
ron deficiency is still common in
A. toddlers
B. adolescent girls
C. women of childbearing age
D. all of the above
D. all of the above
- Decreased iron intake can result from
A. sprue
B. colon cancer
C. adolescent growth spurt
D. red meat–deficient diet
D. red meat–deficient diet
- Faulty iron absorption can result from
A. celiac disease
B. colon cancer
C. adolescent growth spurt
D. menstruation
A. celiac disease
- Pathological iron loss can be caused by
A. sprue
B. colon cancer
C. adolescent growth spurt
D. menstruation
B. colon cancer
- Physiological iron loss can be caused by
A. sprue
B. GI bleeding
C. adolescent growth spurt
D. heavy menstruation
D. heavy menstruation
- Increased iron utilization can be the result of
A. sprue
B. colon cancer
C. adolescent growth spurt
D. menstruation
C. adolescent growth spurt
- The average adult has _____ g of total iron.
A. 0.2 to 1.4
B. 1.5 to 3.4
C. 3.5 to 5.0
D. 5.1 to 10.0
C. 3.5 to 5.0
- 10 and 11. Approximately (10) _____% of iron from food is in the form of (11) _____ iron.
A. 25
B. 50
C. 70
D. 90
D. 90
A. non heme
B. Heme
A. non heme
- The cytochemical stain that can demonstrate iron, hemosiderin, and ferritin is:
A. New Methylene blue
B. Romanowsky
C. Prussian Blue
D. Wright-Giemsa
C. Prussian Blue
- Most ingested iron is readily absorbed into the body in the
A. stomach and duodenum
B. duodenum and upper jejunum
C. ileum and duodenum
D. upper jejunum and ileum
B. duodenum and upper jejunum
- Transferrin represents a
A. storage form of iron
B. beta globulin that moves iron
C. glycoprotein that moves iron
D. both B and C
D. both B and C
- In stage 3 IDA, the erythrocytic indices are typically
A. MCV increased, MCH decreased, and MCHC decreased
B. MCV decreased, MCH decreased, and MCHC decreased
C. MCV decreased, MCH increased, and MCHC decreased
D. MCV decreased, MCH decreased, and MCHC normal
B. MCV decreased, MCH decreased, and MCHC decreased
- The peripheral blood smear demonstrates _____ red blood cells in IDA.
A. microcytic, hypochromic
B. macrocytic, hypochromic
C. macrocytic and spherocytic
D. either a or b
A. microcytic, hypochromic
In ACD, the serum iron is decreased, transferrin saturation is decreased, TIBC is normal or decreased
A. serum iron is severely decreased, and the TIBC is increased
B. serum iron is decreased, and the TIBC is normal/decreased
C. serum iron is normal, and the TIBC is normal
D. serum iron is increased, and the TIBC is normal
B. serum iron is decreased, and the TIBC is normal/decreased
The bone marrow of a patient, previously diagnosed with anemia, was examined because of the lack of a response to vitamin therapy for her fatigue. Prussian Blue staining was performed on a bone marrow smear, but the results were negative. It is likely that this patient is suffering from
A. hemochromatosis
B. iron deficiency anemia
C. chronic blood loss
D. acute blood loss
B. iron deficiency anemia
- Anemias of inflammation/chronic diseases can be caused by
A. inflammation
B. increased hepcidin production
C. malignancy
D. all of the above
D. all of the above
- The typical peripheral blood film of a patient with AOI typically reveals _____ erythrocytes.
A. microcytic, hypochromic
B. macrocytic, hypochromic
C. normocytic, normochromic
D. many spherocytes
- Leukoerythroblastosis can appear as _____ on a peripheral blood smear.
A. immature leukocytes
B. immature erythrocytes
C. immature thrombocytes
D. both A and B
D. both A and B
- What is the most appropriate treatment for anemia of inflammation (AOI)?
A. Red blood cell transfusion
B. Iron therapy
C. Erythropoietin injections
D. Treatment of the inflammatory condition
D. Treatment of the inflammatory condition
- Sideroblastic anemia can be caused by
A. congenital (chromosomal) defect
B. drugs (e.g., chloramphenicol)
C. association with malignant disorders
D. all of the above
D. all of the above
- A common feature of sideroblastic anemia is
A. ringed sideroblasts
B. decreased serum iron
C. decreased serum ferritin
D. macrocytic red blood cells
A. ringed sideroblasts
- The greatest portion of operational body iron is normally contained in what compound?
A. Heme portion of hemoglobin
B. Ferritin
C. Cytochromes
D. mitochondria
A. Heme portion of hemoglobin
- Storage iron in the human body is
A. found in hepatocytes
B. found in macrophages
C. sequestered as ferritin
D. all of the above
D. all of the above
The most sensitive assay for the diagnosis of hereditary hemochromatosis (HH) is
A. serum iron
B. serum iron–binding capacity
C. transferrin
D. transferrin saturation
D. transferrin saturation
Prussian Blue cytochemical staining identifies
A. basophilic stippling
B. Heinz bodies
C. siderotic granules
D. reticulocytes
C. siderotic granules
The bone marrow of a patient, previously diagnosed with anemia, was examined because of the lack of a response to iron therapy. No other laboratory data were available. Examination of the bone marrow revealed an erythroid hyperplasia with an increase (shift to the left) in more mature erythroid precursors. Prussian Blue staining revealed a significantly elevated concentration of storage iron with occasional sideroblasts. It is likely that this patient is suffering from
A. hemochromatosis
B. iron deficiency anemia
C. chronic blood loss
D. acute blood loss
A. hemochromatosis
An acquired disorder of heme synthesis is
A. congenital erythropoietic porphyria
B. lead poisoning
C. hemolytic anemia
D. hemoglobinopathy
B. lead poisoning
When porphyrin synthesis is impaired, the _______ become encrusted with iron.
A. lysosomes
B. nucleoli
C. mitochondria
D. vacuoles
C. mitochondria
The initial condensation reaction in the synthesis of porphyrin preceding heme formation takes place in the (34) _____ and requires (35) _____.
A. liver
B. spleen
C. red bone marrow
D. mitochondria
(35)
A. Iron
B. vitamin B6
C. vitamin B12
D. vitamin D
- D. mitochondria
- B. vitamin B6
The final steps in heme synthesis, including the formation of protoporphyrin, take place in
A. a cell’s nucleus
B. a cell’s cytoplasm
C. the spleen
D. the mitochondria
D. the mitochondria
In reference to case 14.2, the dark staining granules in the red blood cells when a peripheral blood smear stained with Wright-
Giemsa stain is examined represent a defect of
A. membrane development
B. heme synthesis
C. globulin synthesis
D. red blood cell aging
B. heme synthesis
In reference to Case 14.2, the child’s medical history and the appearance of dense, dark-staining particles in some of the red blood cells on a peripheral blood smear suggests a diagnosis of
A. iron deficiency anemia
B. malaria
C. ingestion of lead
D. sickle cell disease
C. ingestion of lead
If globin synthesis is insufficient in a patient, iron accumulates in the cell as _____ aggregates.
A. transferrin
B. ferritin
C. albumin
D. iron
B. ferritin
