18 Flashcards
- Leukocytosis can be caused by
A. increased movement of immature cells out of the bone marrow’s proliferative compartment
B. increased mobilization of granulocytes from the maturationstorage compartment
C. increased movement of granulocytes from the marginating pool to the circulating pool
D. all of the above
D. all of the above
- Neutrophilia can be related to a variety of conditions or disorders. Select the appropriate conditions.
A. Surgery
B. Burns
C. Stress
D. All of the above
D. All of the above
A laboratory assay that can be used to differentiate a leukemoid reaction from chronic myelogenous leukemia is
A. leukocyte alkaline phosphatase (LAP) stain
B. erythrocyte sedimentation rate (ESR)
C. assessment of the shift to the left
D. an absolute neutrophil count
A. leukocyte alkaline phosphatase (LAP) stain
Charcot-Leyden crystals can be found in ______ of patients with active eosinophilic inflammation.
A. sputum
B. tissues
C. stool
D. all of the above
D. all of the above
- Monocytosis can be observed in
A. tuberculosis
B. fever of unknown origin
C. rheumatoid arthritis
D. all of the above
D. all of the above
- Neutropenia can be observed in
A. bone marrow injury
B. nutritional deficiency
C. increased destruction and utilization
D. all of the above
D. all of the above
Cyclic neutropenia is characterized by
A. early manifestation in infants
B. no risk of infection at any phase
C. an abundance of basophils
D. contributing to antibody production
A. early manifestation in infants
- Pseudo–Pelger-Huët anomaly may be associated with the clinical condition of
A. acute infection
B. chronic leukemia
C. iron deficiency anemia
D. aplastic anemia
A. acute infection
- Which of the following is characteristic of Pelger-Huët anomaly?
A. Dark blue-black precipitates of RNA
B. Five or more nuclear segments
C. Failure of the nucleus to segment
D. Precipitated mucopolysaccharides
C. Failure of the nucleus to segment
- Pelger-Huët anomaly may be
A. associated with a deficiency of vitamin B12 or folic acid
B. associated with frequent infections in children or young adults
C. related to a maturational arrest in some acute infections
D. associated with viral infections and burns
C. related to a maturational arrest in some acute infections
Pelger-Huët anomaly can be differentiated from conditions with an increased percentage of neutrophilic bands by the presence of
A. flow cytometry for CD 11b
B. hyposegmentation of neutrophils
C. all bilobed segmented neutrophils
D. both B and C
B. hyposegmentation of neutrophils
- Which of the following is characteristic of hypersegmentation?
A. Dark blue-black precipitates of RNA
B. Five or more nuclear segments
C. Failure of the nucleus to segment
D. Precipitated mucopolysaccharides
B. Five or more nuclear segments
- Hypersegmentation may be
A. associated with a deficiency of vitamin B12 or folic acid
B. associated with frequent infections in children or young adults
C. related to a maturational arrest in some acute infections
D. associated with viral infections and burns
A. associated with a deficiency of vitamin B12 or folic acid
- Which of the following is characteristic of Döhle body inclusions?
A. Gigantic peroxidase-positive deposits
B. Precipitated mucopolysaccharides
C. Dark-blue cytoplasmic inclusions
D. Single or multiple pale-blue staining inclusions
D. Single or multiple pale-blue staining inclusions
- Döhle bodies may be
A. associated with a deficiency of vitamin B12 or folic acid
B. associated with frequent infections in children or young adults
C. related to a maturational arrest in some acute infections
D. associated with viral infections and burns
D. associated with viral infections and burns
- Which of the following is characteristic of toxic granulation?
A. Dark blue-black precipitates of RNA
B. Five or more nuclear segments
C. Failure of the nucleus to segment
D. Precipitated mucopolysaccharides
A. Dark blue-black precipitates of RNA
- In the United States, human diseases caused by Ehrlichia species can be caused by
A. E. chaffeensis
B. E. ewingii
C. E. phagocytophila (similar or identical to)
D. all of the above
D. all of the above
- Ehrlichiosis is transmitted by ______.
A. mosquitoes
B. ticks
C. rats
D. cats
B. ticks
Which of the following is characteristic of May-Hegglin anomaly?
A. Gigantic peroxidase-positive deposits
B. Precipitated mucopolysaccharides
C. Döhle body–like inclusions and giant platelets
D. Single or multiple pale-blue–staining inclusions
C. Döhle body–like inclusions and giant platelets
May-Hegglin can be differentiated from similar conditions by
A. presence of thrombocytosis
B. presence of abnormally large platelets
C. excessively granulated platelets
D. an increase of lymphocytes
B. presence of abnormally large platelets
- Which of the following is characteristic of Chédiak-Higashi syndrome?
A. Gigantic peroxidase-positive deposits
B. Precipitated mucopolysaccharides
C. Döhle body–like inclusions
D. Single or multiple pale-blue staining inclusions
A. Gigantic peroxidase-positive deposits
- Chédiak-Higashi syndrome may be
A. associated with a deficiency of vitamin B12 or folic acid
B. associated with frequent infections in children or young adults
C. related to a maturational arrest in some acute infections
D. associated with viral infections and burns
B. associated with frequent infections in children or young adults
- Chédiak-Higashi syndrome is associated with the
A. neutrophilic series
B. monocytic-macrophage series
C. lymphocytic series
D. erythrocytic series
A. neutrophilic series
- Chédiak-Higashi syndrome can be differentiated from other intracellular inclusions by
A. presence of platelets
B. abnormal inclusions in neutrophils and lymphocytes
C. foamy cytoplasm
D. pyknotic nucleus
B. abnormal inclusions in neutrophils and lymphocytes
Which of the following is characteristic of Alder-Reilly inclusions?
A. Gigantic peroxidase-positive deposits
B. Precipitated mucopolysaccharides (mucopolysaccharidosis)
C. Döhle body–like inclusions
D. Single or multiple pale-blue–staining inclusions
B. Precipitated mucopolysaccharides (mucopolysaccharidosis)
Cytoplasmic inclusion in Alder-Reilly anomaly can resemble
A. Döhle bodies
B. very coarse toxic granulation
C. Auer rods
D. parasites
B. very coarse toxic granulation
The granulocyte disorder most closely associated with cytoplasmic granule fusion is
A. Alder-Reilly anomaly
B. Pelger-Huët anomaly
C. May-Hegglin anomaly
D. Chédiak-Higashi syndrome
A. Alder-Reilly anomaly
Chronic granulomatous disease is associated with the cells of the
A. neutrophilic series
B. eosinophilic series
C. lymphocytic series
D. erythrocytic series
A. neutrophilic series
- Lazy leukocyte syndrome is associated with the
A. neutrophilic series
B. monocytic-macrophage series
C. lymphocytic series
D. erythrocytic series
A. neutrophilic series
- Gaucher’s disease is associated with
A. neutrophilic series
B. monocytic-macrophage series
C. lymphocytic series
D. erythrocytic series
B. monocytic-macrophage series
Niemann-Pick disease is associated with
A. neutrophilic series
B. monocytic-macrophage series
C. lymphocytic series
D. erythrocytic series
B. monocytic-macrophage series
Gaucher’s cells have
A. wrinkled cytoplasm
B. one to three nuclei
C. a deficiency of β-glucocerebrosidase
D. all of the above
C. a deficiency of β-glucocerebrosidase
Based on the history and laboratory data presented in case study
18.1, what is a likely diagnosis in this case?
A. Hemolytic anemia
B. Bacterial infection
C. Allergic reaction
D. Parasitic infection
D. Parasitic infection
Based on the history and laboratory data presented in case study
18.2, what is a likely diagnosis in this case?
A. Iron deficiency anemia
B. Acute inflammation
C. Chronic fungal infection
D. A viral infection
B. Acute inflammation
Based on the history and laboratory data presented in case study
18.3, what is a significant laboratory observation in this case?
A. Toxic granulation
B. Ehrlichia morulae
C. Increased number of vacuoles
D. Hyposegmentation of neutrophils
A. Toxic granulation
Based on the history and laboratory data presented in case study
18.4, what is the most significant laboratory observation in this case?
A. Severe allergic reaction
B. Increase in lymphocytes
C. Increase in band neutrophils
D. Increase in platelets
C. Increase in band neutrophils
Based on the history and laboratory data presented in case study
18.5, what is a significant laboratory observation in this case?
A. Toxic granulation
B. Döhle bodies
C. Malaria
D. Lymphocytopenia
B. Döhle bodies
Based on the history and laboratory data presented in case study
18.6, what is a likely diagnosis in this case?
A. Chédiak-Higashi syndrome
B. Gaucher’s disease
C. Lymphocytic leukemia
D. Iron deficiency anemia
B. Gaucher’s disease
Based on the history and laboratory data presented in case study
18.7, what is the most significant routine laboratory finding in this case?
A. neutrophilia
B. lymphocytosis
C. anemia
D. thrombocytosis
A. neutrophilia
