15 Flashcards
The most common cause of nonmegaloblastic macrocytic anemia
is
A. hemolytic anemia
B. reticulocytosis
C. alcoholism
D. pernicious anemia
C. alcoholism
Which of the following is more typical of nonmegaloblastic than megaloblastic anemia?
A. Oval macrocytes
B. Round macrocytes
C. Howell-Jolly bodies
D. Hypersegmented neutrophils
A. Oval macrocytes
- Megaloblastic anemias can be caused by
A. tapeworm infestation
B. gastric resection
C. nutritional deficiency
D. all of the above
D. all of the above
- Megaloblastic anemia related to folic acid deficiency is associated with
A. abnormal absorption
B. increased utilization
C. nutritional deficiency
D. all of the above
D. all of the above
In megaloblastic anemia, the typical erythrocytic indices are
A. MCV increased, MCH increased, and MCHC normal
B. MCV increased, MCH variable, and MCHC normal
C. MCV increased, MCH decreased, and MCHC normal
D. MCV normal, MCH increased, and MCHC normal
A. MCV increased, MCH increased, and MCHC normal
Which of the following can be found in a patient with classic megaloblastic anemia?
A. Ovalocytes and hypersegmented neutrophils
B. Hypochromic macrocytes and variant lymphocytes
C. Howell-Jolly bodies and Pappenheimer bodies
D. Lymphocytosis
A. Ovalocytes and hypersegmented neutrophils
Which laboratory assays are most sensitive to decreased levels of cobalamin?
A. RBC folate and serum folate
B. RBC folate and serum cobalamin
C. Transcobalamin assays
D. Homocysteine and MMA
C. Transcobalamin assays
The underlying type A gastritis that causes pernicious anemia is immunologically related to
A. autoantibody to IF
B. low serum gastrin
C. autoantibody to parietal cells
D. both A and C
D. both A and C
A lack of intrinsic factor could be due to
A. gastrectomy
B. cobalamin deficiency
C. folate deficiency
D. large bowel resection
A. gastrectomy
Cobalamin transport is mediated by
A. IF
B. TC II
C. R proteins
D. all of the above
D. all of the above
- In a case of classic pernicious anemia, the patient has
A. leukopenia
B. hypersegmented neutrophils
C. anemia
D. all of the above
D. all of the above
- The reticulocyte count in a patient with untreated pernicious anemia is characteristically
A. 0%
B. 0.3%
C. <1.0%
D. approximately 1.8%
C. <1.0%
- In pernicious anemia, serum haptoglobin–binding capacity is
A. decreased
B. normal
C. increased
D. significantly increased
A. decreased
- In pernicious anemia, serum B12 is
A. decreased
B. normal
C. increased
D. significantly increased
A. decreased
- In pernicious anemia, folate is
A. decreased
B. normal
C. increased
D. significantly increased
B. normal
- In pernicious anemia, serum iron is
A. decreased
B. normal
C. increased
D. significantly increased
C. increased
- In pernicious anemia, percent transferrin is
A. decreased
B. normal
C. increased
D. significantly increased
C. increased
- In pernicious anemia, serum LDH is
A. decreased
B. normal
C. increased
D. significantly increased
D. significantly increased
- In pernicious anemia, unconjugated bilirubin is
A. decreased
B. normal
C. increased
D. significantly increased
C. increased
The liver stores enough folate to meet daily requirement needs for how long?
A. 1 month
B. 6 to 8 weeks
C. 3 to 6 months
D. 1 year
C. 3 to 6 months
The peripheral erythrocyte morphology in folate deficiency is similar to pernicious anemia, and the RBCs are
A. small
B. normal size
C. large
C. large
If an older patient has a history of malnutrition, macrocytosis, and pancytopenia but no other known abnormalities, what type of anemia would be the likely diagnosis?
A. Celiac disease
B. Cobalamin deficiency
C. Pernicious anemia
D. Folic acid deficiency
B. Cobalamin deficiency
Folic acid deficiency can be caused by
A. vitamin B12 deficiency
B. chronic blood loss
C. strict vegetarian diet
D. vitamin B6 deficiency
C. strict vegetarian diet
