12. CPR Automonics Flashcards
SA node parasym innervation:
Via:
Receptor:
Action:
Effect:
Via: Vagus N
Receptor: Muscarinic
Action: decrease rate of depol
Effect: slow HR
SA node sym innervation
Via:
Receptor:
Action:
Effect:
Via: fibers from T1-T5
Receptor: Beta-1
Action: increase rate of depol
Effect: increase HR
AV node parasym innervation
Via:
Receptor:
Action:
Effect:
Via: Vagus N
Receptor: Muscarinic
Action: decrease slope of pacemaker potential & depol rate during phase 0
Effect: decrease conduction velocity thru AV node/ventricles
AV node sym innervation
Source:
Receptor:
Action:
Effect:
Source: T1-T5
Receptor: Beta-1
Action: increase rate of depol during phase 0 & pacemaker potential
Effect: incresae conduction velocity thru AV node
Atrial myocyte parasym innervation
Source:
Receptor:
Action:
Effect:
Source: vagus N
Receptor: muscarinic
Action: decrease Ca into myocyte
Effect: decrease atrial contractilty & maybe ventricular contractility too
Atrial & ventricular myocyte sym innervation
Source:
Receptor:
Action:
Effect:
Source: T1-T5
Receptor: Beta 1
Action: increase Ca into myocytes
Effect: increase myocyte contractility (cardiac M pumps harder)
Cerebral vasculature sym innervation
Source:
Receptor:
Action:
Effect:
Source: local
Receptor: Alpha-1
Action: contraction of vascular smooth M
Effect: vasoconstriction
when is cerebral vasculature stimulated by the sym system
systemic BP = high enough to damage cerebral capillaries
-constrictionof the small As decrease blood flow thru caps to protect them
Coronary A parasym innervation
Source:
Receptor:
Action:
Effect:
Source: vagus N
Receptor: muscarinic
Action: relax smooth M
Effect: vasodilate and increase coronary blood flow
Coronary A symp innervation
Source:
Receptor:
Action:
Effect:
Source: T1-T5
Receptor: alpha-1
Action: contract smooth M
Effect: vasoconstrict to decrease blood flow (short lived)
why is vasoconstriction of coronary A short lived
bc this will increase metabolic need
and lead to vasodilation that overcomes the sym effect
cutaneous vasculature sym innervation
Source:
Receptor:
Action:
Effect:
Source: multiple
Receptor: alpha 1
Action: contract vascular smooth M
Effect: vasoconstrict
how are sweat glands innervated
sympathetic muscarinic
relax vascular smooth m
–> vasodilate to increase primary sweat production
skeletal M vasculature sym innervation
Source:
Receptor:
Action:
Effect:
Source: multiple
Receptor: alpha 1 & beta 2
Action: alpha 1- contract vascular smooth M & beta-2 relax it
Effect: alpha 1: vasoconstrict
beta 2: vasodilate
splanchnic vessels sym innervation
Source:
Receptor:
Action:
Effect:
Source: T5-L2
Receptor: alpha 1
Action: contract vascular smooth m
Effect: vasoconstriction of splanchnic BV
which ganglion are involved in the splanchic vessel sym innervation
celiac ganglion
superior mesenteric ganglion
inferior mesenteric ganglion
when do splanchnic vessels vasodilate
when sym activity is decreased
sym innervation of Vs
Source:
Receptor:
Action:
Effect:
Receptor: alpha 1, 2 & beta 2
Action:
- alpha 1: contract venous smooth m
- alpha 2 & beta 2: relax it
Effect:
- alpha 1: contract V –> increase blood return to heart
- alpha 2/beta: dilate –> slow return to heart
pulmonary vasculature parasym innervation
Source:
Receptor:
Action:
Effect:
Source: vagus
Receptor: muscarinic
Action: direct = produce NO and release from endothelial cells & indirect = use NO & relax vascular smooth M
Effect: vasodilation
where is pul vasculature innervated more
most: extrapul As (pul A and pul trunk)
decrease as you move closer to alveoli
pul vasculature sym innervation
Source:
Receptor:
Action:
Effect:
Source: first 5 thoracic ganglia
Receptor: primarily alpha 1 but also have beta 1 & beta 2
Action: alpha 1: contract vascular smooth M & beta 1/2: relax it
Effect: alpha 1- vasocontrict
beta 1/2 vasodilate
how else can ANS activity be activated for pul vasculature
mechanoreceptors - detect distention
& exposure to cold air or hypoxia
nasal mucosa parasym innervation
Source:
Receptor:
Action:
Effect:
Source: trigemial N and sphenopalatine ganglion
Receptor: muscarinic
Action: vasodilate
Effect: increase mucus secretion
nasal mucosa sym innervation
Source:
Receptor:
Action:
Effect:
Source: superior cervial ganglia via CN VII
Receptor: alpha 1
Action: indirectly contract smooth M
Effect: reduce mucus production
lower airway, extrinisic parasym innervation
Source:
Receptor:
Action:
Effect:
Source: vagus N
Receptor: muscarinic
Action/Effect: bronchoconstriction & increased mucus synthesis
lower airways (bronchial), extrinsic sym innervation
Source:
Receptor:
Action:
Effect:
Source: T1-T5
Receptor: beta 2
Action: relax bronchial smooth M
Effect: bronchodilation & slightly increase secretions
what are the vascular components of the bowman’s capsule
afferent arterioles: blood flow to glomerular capillaries
glomerular capillaries: deliver blood/plasma so plasma can be filtered
efferent arterioles: blood flow out of glomerular capillaries
what is the vascular component of the proximal convoluted tubule
peritubular capillaries: secrete substance into proximal convoluted tubules to be excreted in urine & reabsorb things that were filtered out but are actually needed
( = efferent arterioles are broken down into these)
what is the vasa recta
blood supply of the loop of henle
= secrete Na, Cl & K & reabsorb h2o to keep interstitium concentrated
what is the blood supply os the distal convoluted tubule/collecting duct
perituular capillaries
= reabsorb Na & h2o
hormonally controlled by ADH & Aldosterone
kidney vasculature sym innervation
Receptor:
Action:
Effect:
Receptor: alpha adrenergics
Action: contract vascular smooth M
Effect: vasoconstrict - renal A, afferent & efferent arterioles
==> decrease blood flow to kidney–> decrease urine production
justaglomerular apparatus sym innervation
Receptor:
Action:
Effect:
=granule cells of afferent arterioles
Receptor: Beta-1
Action: increase release of renin
Effect:
- increase angiotensin & angiotensin II production
- angiotensin cuases increased releast of aldosterone
- aldosterone increases Na reabsorption & release ADH
- ADH increase h2o resorptio ==> INCREASE BLOOD VOLUME
