病毒性疾病與致病機轉 Flashcards

1
Q

疾病發生的三個成因?

A

1.致病原
2.傳染途徑
3.宿主本身易感性

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2
Q

病毒的感染途徑?

A

Attachment-Penetration-Uncoating-Assembly-Release-Infecting virus

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3
Q

登革熱患者不建議使用什麼藥物?

A

阿斯匹靈

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4
Q

使病毒初級感染的細胞有甚麼特徵?

A

1.具有receptor
2.支持病毒複製

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5
Q

次級感染的散播方式有?

A

1.直接感染
2.血液
3.淋巴系統
4.巨噬細胞
5.腦脊髓液

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6
Q

透過呼吸道傳播的有哪些病毒?

A

流感病毒、水痘-帶狀皰疹病毒

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7
Q

透過糞口傳播的有哪些病毒?

A

輪狀病毒、諾羅病毒、腺病毒

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8
Q

透過人畜共通傳播的有哪些病毒?

A

登革熱病毒

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9
Q

透過母子垂直傳播的有哪些病毒?

A

德國麻疹病毒

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10
Q

造成腦炎的有哪些病毒?

A

HSV-1、狂犬病毒

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11
Q

HSV病毒會有哪些症狀?

A

1.口腔炎
2.結膜炎
3.腦炎

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12
Q

病毒感染細胞後,可進行完整生命週期的叫做?

A

容許性細胞

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13
Q

病毒感染細胞且無法進行複製叫做?

A

流產式感染

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14
Q

病毒感染細胞,釋放子代造成細胞死亡叫做?

A

溶解性感染

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15
Q

病毒感染細胞細胞存活且正常病毒複製叫做?

A

持續性感染

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16
Q

病毒感染細胞,存活但未進行複製叫做?

A

潛伏性感染

17
Q

B型克沙奇病毒的目標細胞為?

A

心臟、肌肉、腺體

18
Q

Negri小體成因?

A

狂犬病毒脫去的蛋白質外殼引起嗜酸性顆粒凝集

19
Q

貓頭鷹眼成因?

A

巨細胞病毒與腺病毒引起的細胞融合與嗜酸性濃縮

20
Q

cowdry A型小體成因?

A

單純皰疹、帶狀皰疹、巨細胞與黃熱細胞的嗜酸性濃縮

21
Q

B肝病毒利用表面抗原和APC的什麼結合,使細胞進入休眠狀態?

A

CD33

22
Q

隱藏以避開抗體的病毒?

A

皰疹、反轉錄

23
Q

形成融合體的?

A

單純皰疹、水痘帶狀皰疹、副黏液、人類免疫缺乏

24
Q

抗原會變化的病毒?

A

慢性病毒
流感

25
Q

分泌阻斷性抗原的病毒?

A

B肝

26
Q

阻斷干擾素製造的病毒?

A

B肝
EB病毒

27
Q

阻斷干擾素作用的病毒?

A

腺病毒
單純皰疹病毒

28
Q

減損樹突細胞功能的病毒?

A

麻疹、C肝

29
Q

減損淋巴球的病毒?

A

單純皰疹(CD8 T)
人類免疫缺乏(CD4 T、巨噬細胞)
麻疹(NK, T B cell)

30
Q

免疫抑制引子的病毒?

A

EB病毒

31
Q

減少MHC I呈現的病毒?

A

腺病毒12
巨細胞病毒
單純皰疹病毒

32
Q

抑制發炎反應的病毒?

A

痘病毒、腺病毒