傳染免疫 Flashcards

1
Q

先天性免疫在細菌入侵後幾小時出現?

A

4~96小時

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2
Q

引發apoptosis的是哪種補體?

A

C5b6789

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3
Q

引起inflammation的是哪一種補體?

A

C5a、C3a

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4
Q

抗病毒比較有效的是?

A

NK、IFN

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5
Q

抗細菌比較有效的是?

A

IL-1、TNF-a、CXCL8

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6
Q

PAMP-PRR例子?

A

1.Peptidoglycan-NOD1&2
2.LPS-TLR4
3.Flagellin-TLR5

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7
Q

在細胞質內辨識的是?

A

Peptidoglycan-NOD1&2

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8
Q

CXCL8又叫做什麼?是誰的附著因子?

A

1.IL-8
2.嗜中性球、巨噬細胞

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9
Q

產生protective effect,使血小板堆積造成血液凝固的是?

A

IL-1、TNF-a

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10
Q

胞外免疫反應有哪些?

A

1.抗體(ex. sIgA)
2.補體
3.吞噬作用
4.抗微生物胜肽
5.ILCs2&3

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11
Q

胞內免疫反應有哪些?

A

1.NK cell
2.Tc cell
3. macrophage
4.TH&ILCs1

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12
Q

NK被什麼活化?分泌什麼?

A

1.IL-12
2.IFN-r、perforin、granzyme

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13
Q

ILC1被什麼活化?分泌什麼?

A

1.IL-12
2.IFN-r

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14
Q

ILC2被什麼活化?分泌什麼?

A

1.IL-25、IL-33、TSLP
2.IL-5、IL-13

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15
Q

ILC3被什麼活化?分泌什麼?

A

1.IL-23
2.IL-22、IL-17

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16
Q

主要對抗細胞外寄生蟲的是?

A

ILC2

17
Q

致病機轉只有毒素,可用累毒素製造疫苗或是用抗體中和毒素的是?

A

白喉桿菌、霍亂弧菌、破傷風桿菌

18
Q

致病機轉為只會入侵身體,需要靠細胞免疫的是?

A

痲瘋分枝桿菌

19
Q

金黃葡萄球菌躲避免疫機轉?

A
  1. Protein A跟Fc結合
    2.凝固酶把纖維蛋白沉積在細菌表面,阻止吞噬作用
20
Q

肺炎鏈球菌躲避免疫機轉?

A

夾膜抗原多樣性

21
Q

淋病雙球菌躲避免疫機轉?

A
  1. IgA protease
    2.線毛蛋白抗原多樣性
22
Q

化膿性鏈球菌躲避免疫機轉?

A
  1. C5a peptidase
  2. srerptolysin O
23
Q

能從吞噬泡中逃脫的是?

A

李斯特菌、志賀氏菌

24
Q

阻止吞噬泡跟溶酶體結合的是?

A

結核桿菌

25
Q

改變吞噬溶酶體pH值,使酵素不能作用的是?

A

科克氏菌(引起Q fever)

26
Q

布氏錐形蟲躲避免疫機轉?

A

1.抵抗抗體
2.基因轉換

27
Q

瘧原蟲抵抗免疫機轉?

A

1.抗原變化
2.躲進紅血球