Y5 - Chemotherapy, hormone therapy & biological agents Flashcards
def
a type of cancer treatment which uses anti-cancer drugs
when may chemotherapy be used
with the intent of curing the patient
or to prolong life
what sort of therapy is chemotherapy
a systemic therapy
who is HRT used for
menopausal women
who is ART used for
males with low testosterone
indications
cancer, rheumatoid arthritis, SLE, MS
complications
myelosuppression (causing immunosuppression), mucositis, alopecia
different types of chemotherapeutic agents
akylating agents antimetabolites antimicrotubule agents topoisomerase inhibitors cytotoxic antibiotics
how do akylating agents work
akylate RNA and DNA
if DNA tries to replicate, or repair akylation, DNA strands break and apoptosis occurs
how do antimetabolites work
impede DNA and RNA synthesis
block enzymes required for DNA synthesis
how do anti-microtubule agents work
block cell division by preventing microtubule function
how do topoisomerase inhhibitors work
interferes with DNA unwinding
