Gastric Cancer Flashcards
def
stomach cancer is a tumour in any part of the stomach
what are the most common gastric cancers
adenocarcinomas
what are less common gastric cancers
lymphoma
leiomyosarcoma
epi
men>women
more common in east asia (china, japan)
aetiology
consumption of smoked and salted foods
lack of refrigeraion
what infection is associated with gastric cancer
h pylori
how does h pylori increase risk of gastric cancer
increases mutations in p53
what tumour suppressor gene is associated with gastric cancer
mutated p53 (loss of tumour suppressor function)
what proto-oncogenes are associated with gastric cnacer
ras
c-myc
what are risk factors for gastric cancer
STOMACH
Smoking, Smoked foods, Syndromes (Lynch syndrome) Talcum powder Obesity Menetriers DIsease Anaemia (pernicious), Alcohol Chronic ulcer or gastritis H. pylori or High salt diet
features of gastric cancer
LIONS
Lump (epigastric)
Insidious onset symptoms (epigastric pain and weight loss)
Obstructive features
New onset dyspepsia
Silent presentation (lymph nodes such as virchows node, sister mary josephs nodule, irish node)
patients are commonly elderly and male with a smoking background and FHx of GC
what is virchows node
left supraclavicular node
what is sister mary josephs nodule
periumbilical nodule
what is irish node
left axillary node
what is the first line investigation for GC
upper GI endoscopy with biopsy
-ulcer or mass
