Breast Cancer Flashcards
def of breast cancer in situ
breast cancer confined to the duct or lobule
does not extend beyond the basement membrane
what is ductal carcinoma in situ
precursor to invasive carcinoma
what are the different types of breast cancer in situ
DCIS
LCIS
what does DCIS increase risk of
invasive breast cancer at site of biopsy
what does LCIS increase risk of
invasive breast cancer in either breast
which was more common DCIS or LCIS
DCIS (85%)
LCIS (15%)
epi
elderly
what does HRT increase risk of
invasive breast cancer
what does HRT not have an affect on
DCIS
aetiology of DCIS
proliferation of malignant appearing epithelial cells which have not penetrated the basement membrane
where is the origin of most DCIS
terminal duct lobular lesions
what is the progression of benign disease to invasive breast cancer
1 typical hyperplasia
2 atypical hyperplasia
3 DCIS
4 invasive breast cancer
what receptor is associated with DCIS
oestrogen receptor
what marker is used to guide therapy with DCIS
HER2
is HER2 more highly expressed in DCIS or invasive breast cancer
DCIS
how does oestrogen play a role in breast cancer in situ
higher oestrogen levels (women) stimulate proliferation of breast epithelial cells in lobules and ducts
mutations occur in these epithelial cells