(XIII)Spiral bacteria (2)*Helicobacter pylori Flashcards
Characterize (4) : H. pylori
(1) Motile
(2) Curved gram (-)
(3) Urease (+)
(4) Oxidase (+)
H. pylori infection
Transmission: […]
Clinical presentation
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H. pylori infection
Transmission: Faecal oral/oral-oral (wait what???)
Clinical presentation
- Symptoms develop after 2 weeks: abdominal pain, flatulence, nausea, bad breath (but most acute infections are inapparent and never diagnosed)
- Chronic active gastritis: leads to peptic ulceration (duodenal, gastric), gastric adenocarcinoma and gastric MALT lymphoma (rare)
MALT = mucosa-associated lymphoid tissue
I found a really nice pic LOL. Look at the triple therapy drugs. Cutes~
How to diagnose H. pylori infection?
Non-invasive tests (for younger patients with dyspepsia, without alarm symptoms)
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Invasive tests (BIOPSY! Endoscoe to check for cancerous lesions in older patients and those with alarm symptoms)
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How to diagnose H. pylori infection?
Non-invasive tests (for younger patients with dyspepsia, without alarm symptoms)
- Urea breath test (drink solution of urea with 14-C, detect labeled CO2 exhaled)
- Stool antigen test
- Serology (false positives can occur in patients who have been recently treated, reflects past infection. Hence cannot test for “cure”
Invasive tests (BIOPSY! Endoscoe to check for cancerous lesions in older patients and those with alarm symptoms)
- Microscopy (histology)
- Culture (from gastric biopsies taken through a fibre optic endoscope)
- Rapid urease test (add biopsy to small volume of urease broth, observe pH change)
Both urea breath test and stool antigen test can be false negative due to use of antibiotics, PPI and acute bleeding. Should test a few weeks after stopping these drugs.
triple therapy for h.pylori: […]
triple therapy for h.pylori: clarithromycin + amoxicillin + omeprazole
“Crows, Ammo box, PPI inhibitor”
Plus a cute picture FOC.
