(VIII)Sporing Anaerobic Gram Positive Rods (2) Clostridium Botulinum Flashcards
Characterize (3) : Clostridium botulinum
(1) Gram (+) rod
(2) Spores
(3) Obligate anaerobe
Clostridium Botulinum infection
Transmission: Contact with wound or food poisoning (canned food).
Virulence factor & Mechanism: […]
Clinical Presentation:
[…]
- Early signs: […]
- Severe conditions: […]
Treatment:
[…]
Clostridium Botulinum infection
Transmission: Contact with wound or food poisoning (canned food).
Virulence factor & Mechanism: Botulinum toxin: blocks Ach release at NMJ (flaccid paralysis)
Clinical Presentation:
Botulism (flaccid paralysis)
- Early signs: diplopia, dysphagia, ptosis, nausea, vomiting, usually no fever
- Severe conditions: paralysis of respiratory muscles (death!!)
Treatment:
Antiserum + ventilate
Note that there is
- infant botulism (constipation, dysphagia, muscle weakness “floppy baby”) and
- wound botulism (esp in IVDAs) (adult botulism symptoms - GIT symtomps + fever and elevation of white count) as well.
Adults usually ingest pre-formed toxin, infants usually ingest spores which then produces the toxins in the gut.