(II) Gram Negative Rods - (6) Shigella spp. Flashcards
Name 3 ways you can distinguish Shigella from Salmonella
Shigella Salmonella
Green on Hektoen Black on Hektoen
Immotile Motile
Acid stable Acid labile
Describe how Shigella infects cells
(1) Induces phagocytosis by M-cells
(2) Uses actin filaments to escape
(Once escaped, it’s phagocytosed by MΦs, and then induces apoptosis and subsequent Inflammation.)
What type of diarrhea does Shigella cause?
(1) Inflammatory
(2) ⇒ Bloody
What population gets HUS from Shigella?
Children <10 years old
(Due to Shigella DYSENTERIAE. Also associated with Reitter’s syndrome.)
MOA: Shiga toxin
Inhibits 60s ribosome
Name 3 enteric bacteria with Type III secretion systems
(1) Shigella
(2) Salmonella
(3) Y. enterocolitica
Clinical presentation of Shigella:
(Depends on which strand)
1. Sh. dysenteriae: […]
2. Sh. sonnei: […]
Clinical presentation of Shigella:
(Depends on which strand)
1. Sh. dysenteriae: Dysentry (frequent passage of blood-stained mucopurulent stools, may be complicated by Hemolytic-uremic syndrome from Shiga toxin)
2. Sh. sonnei: common cause of mild diarrhoeal disease (outbreaks in institutions)
Shigella is one of the leading bacterial causes of […] worldwide, causing an estimated 80–165 million cases
It is closely related to E.coli.
Transmission:
[…]
Shigella is one of the leading bacterial causes of diarrhea worldwide, causing an estimated 80–165 million cases
It is closely related to E.coli.
Transmission:
Faecal-oral, flies (most infections are transmitted from person to person. Very low dose is required for infection)