(III) Fastidious Gram Negative Rods (4) Bordetella spp. Flashcards
What is the vaccine for Pertussis?
DTaP
Name the protein responsible for Pertussis’ ability to attach to human cells
Filamentous hemagglutinin
MOA: Pertussis toxin
ADP Ribosylation of Gi ⇒ ↑ cAMP
What is the effect of ↑ cAMP due to Pertussis toxin?
Lymphocytosis
Name 3 toxins associated with Pertussis
(1) Pertussis toxin
(2) Adenylate cyclase toxin
(3) Tracheal toxin
(Trachea ∝ Tractor)
What is the effect of Trachea toxin?
Damages ciliated respiratory epithelium
Which phase of Pertussis has the characteristic whooping cough?
Paroxysmal
(Catarrhal → Paroxysmal → Convalescent)
How long does the convalescent stage of Pertussis last?
Up to several months
ROT: Pertussis
Respiratory droplets
Treatment: Pertussis
Macrolides
(Macrolides are not as helpful once toxins are circulating)
Bordetella pertussis infection
Transmission: […]
Classic Clinical Presentation:
[…]
- […]
- […]
Bordetella pertussis infection
Transmission: respiratory droplets
Classic Clinical Presentation:
whooping cough
- Catarrhal stage: resemble other respiratory infections (low-grade fever, runny nose, sneezing, mild cough. This is the most contagious stage)
- Paroxysmal stage: bursts of paroxysmal cough (lungs emptied in a series of 5-20 cough before inspiratory gasp through a narrowed throat which produces the ‘whoop’), once this stage is established, may persist for several months (convalescent stage)
“Pertussis means “violent cough.” Bordetella pertussis causes whooping cough”
Included in DTaP (Diptheria-Tetanus- acellular Pertussis) vaccine.
Tdap is the same, just that smaller letter = less amount of d and ap lol.