(III) Fastidious Gram Negative Rods (9)Yersinia spp.

Question 1

Characterize (3) : Yersinia enterocolitica

Answer 1

(1) Gram (-) rod
(2) Bipolar staining
(3) Encapsulated

Question 2

ROT: Y. enterocolitica

Answer 2

(1) Puppy feces
(2) Contaminated milk

Question 3

Who most commonly gets Y. enterocolitica infections?

Answer 3

Small children

Question 4

Name 2 signs/symptoms of Y. enterocolitica

Answer 4

(1) Bloody diarrhea
(2) Pancreatitis/Paralytic ileus/etc

Question 5

What organism can cause a pseudo-appendicitis?

Answer 5

Y. enterocolitica

Question 6

Reservoir: Y. pestis

Answer 6

Prairie dogs / Rodents

(In SW USA, Central Africa, and Madagascar)

Question 7

Vector: Y. pestis

Answer 7

Fleas

Question 8

What is the most distinctive sign of Y. pestis

Answer 8

Buboes

Question 9

What does Y. pestis secrete with its type III secretion system?

Answer 9

Yops (Yersina outer proteins)

(⇒ Neutrophil/MΦ dysfunction)

Question 10

Treatment: Y. pestis

Answer 10

Streptomycin + Tetracycline

Question 11

What type of vaccine does Y. pestis have?

Answer 11

Killed

Question 12

Yersinia enterocolitica/Yersinia pseudotuberculosis infection

Clinical presentation:
[…]

Answer 12

Yersinia enterocolitica/Yersinia pseudotuberculosis infection

Clinical presentation:

• Gastroenteritis
• mesenteric lymphadenitis, ileitis
• septicemia

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- pseudo appendicitis (infection that mimics)
- bloody diarrhea

Question 13

Yersinia pestis infection

Transmission: […]

Clinical presentation:
[…]

Diagnosis: […]

Answer 13

Yersinia pestis infection

Transmission: zoonotic - usually through rat flea bite

Clinical presentation:
- Bubo formation (painful swelling of lymph node)
- subsequent invasion of bloodstream leading to pneumonia and septicemia

Diagnosis: Microscopy and culture of sputum/blood