(IX)MicroB Bacteria Little or no peptidoglycan (1)*Chlamydia trachomatis Flashcards
Characterize (3) : Chlamydia spp.
(1) Poor gram staining pleomorph
(2) Obligate intracellular
(3) No muramic acid in cell wall
(Chlamydia is obligate intracellular because it cannot synthesize its own ATP)
Chlamydia and Chlamydophilia spp. are obligate intracellular pathogens with little peptidoglycan.
Name the 3 clinically relevant organisms in this spp.
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Chlamydia and Chlamydophilia spp. are obligate intracellular pathogens with little peptidoglycan.
Name the 3 clinically relevant organisms in this spp.
- C. trachomatis
- Ch. psittaci
-** Ch. pneumoniae**
Chlamydia trachomatis infection (vvv. IMPT)
Transmission
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Clinical Presentation:
Oculogenital Biovars A, B, Ba, C:
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Lymphogranuloma venereum (LGV) Biovars L1, L2, L3 (STD):
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Oculogenital Biovars D – K (STD):
In males:
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In females:
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Both genders:
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In neonates:
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Chlamydia trachomatis infection (vvv. IMPT)
Transmission
- “Fingers, Flies, Fleas” (Oculogenital Biovars A, B, Ba, C)
- STD (LGV L1, L2, L3 & Oculogenital Biovars D-K)
Clinical Presentation:
Oculogenital Biovars A, B, Ba, C:
- Trachoma (eye infection eventually leading to blindness)
- Eye infection (recurrent)
- Scarring of eyelids (eye lashes turn in, corneal damage and clouding, eventually blindness)
Lymphogranuloma venereum (LGV) Biovars L1, L2, L3 (STD):
- Genital ulcer disease
- Primary lesion: small papule/vesicle on genitalia
- Lymph node enlarge and suppurate (Elephantiasis of genitals)
- Proctitis, rectal stricture (females, male homosexuals)
Oculogenital Biovars D – K (STD):
In males:
- Urethritis (NGU/PGU), epididymitis
- Reactive arthritis
- Conjuctivitis/uveitis, urethritis/cervicitis, SARA (Reiter’s syndrome)
- Proctitis in MSM
In females:
- urethritis, proctitis
- PID (salpingitis, oophoritis, endometritis) (risk of infertility and ectopic pregnancy increases with recurrent infection)
- Fitz-Hugh-Curtis syndrome
Both genders:
- adult inclusion conjunctivitis due to autoinfection with fingers (paratrachoma)
In neonates:
- ophthalmia neonatorum (due to endocervical infection in mother), pneumonia, staccato cough (different incubation period from N. gonorrhea)
Presentation of biovars D-K very similar to N. gonorrhoea
NGU = Non-Gonococcal Urethritis
PGU = Post-Gonococcal Urethritis
What are the 2 major organisms that causes PID?
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What are the 2 major organisms that causes PID?
Chlamydia trachomatis & Nisseria gonorrhoeae
What is the lab diagnosis for C. trachomatis serotype D-K?
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What is the lab diagnosis for C. trachomatis serotype D-K?
MOLECULAR METHODS!!!
- Nuclear acid tests (NAT), PCR
No cell wall uh, gram stain quite useless
