White blood cells- Normal and malignant Flashcards
Aidan
What is haematocrit?
The amount of RBC’s in the taken volume of blood.
What can a full blood count tell you about platelets?
Platelet numbers and size distribution.
What can a full blood count tell you about RBC’s?
Information on;
- Haemoglobin (Hb).
- Haematocrit,
- Mean cell volume (MCV).
- Red cell count (RBC).
What can a full blood count tell you about WBC’s?
WBC numbers, “differential” count of subtypes, any abnormal cells detected by instrument and blood film.
What is in the bottom of blood test vials?
Anticoagulant that stops the blood from clotting.
WBC’s are a large proportion of the blood compared to plasma and RBC’s, true or false?
False, they are a small proportion of blood volume.
What does staining blood films allow us to do?
It allows us to determine the difference between different WBC’s.
What can a white blood cell differential (and blood film) tell us?
- Evidence of, and response to infection.
- Allergic response.
- Leukaemia
- marrow infiltration.
What are some additional WBC tests we can do and what do they tell us?
- Flow cytometry to show lymphoid and myeloid populations + cell maturity.
- Cytogenetics
- Gene sequencing to look for specific mutations.
How do we take a bone marrow examination and what can it tell us?/tests can we do?
Take a core of bone marrow, can be used to assess number and type of normal/abnormal cells, same range of tests as per FBC.
How do embryological stem cells move from yolk sac to adulthood?
- Embryological stem cells form “blood islands” in yolk sac.
- Cells migrate to liver then spleen then bone marrow in foetus.
- At birth bone marrow is widely distributed then retreating to axial skeleton by adulthood.
Name the three types of granulocytes
neutrophils, eosinophils and basophils.
