White blood cells- Normal and malignant Flashcards

Aidan

1
Q

What is haematocrit?

A

The amount of RBC’s in the taken volume of blood.

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2
Q

What can a full blood count tell you about platelets?

A

Platelet numbers and size distribution.

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3
Q

What can a full blood count tell you about RBC’s?

A

Information on;

  • Haemoglobin (Hb).
  • Haematocrit,
  • Mean cell volume (MCV).
  • Red cell count (RBC).
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4
Q

What can a full blood count tell you about WBC’s?

A

WBC numbers, “differential” count of subtypes, any abnormal cells detected by instrument and blood film.

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5
Q

What is in the bottom of blood test vials?

A

Anticoagulant that stops the blood from clotting.

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6
Q

WBC’s are a large proportion of the blood compared to plasma and RBC’s, true or false?

A

False, they are a small proportion of blood volume.

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7
Q

What does staining blood films allow us to do?

A

It allows us to determine the difference between different WBC’s.

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8
Q

What can a white blood cell differential (and blood film) tell us?

A
  • Evidence of, and response to infection.
  • Allergic response.
  • Leukaemia
  • marrow infiltration.
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9
Q

What are some additional WBC tests we can do and what do they tell us?

A
  • Flow cytometry to show lymphoid and myeloid populations + cell maturity.
  • Cytogenetics
  • Gene sequencing to look for specific mutations.
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10
Q

How do we take a bone marrow examination and what can it tell us?/tests can we do?

A

Take a core of bone marrow, can be used to assess number and type of normal/abnormal cells, same range of tests as per FBC.

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11
Q

How do embryological stem cells move from yolk sac to adulthood?

A
  • Embryological stem cells form “blood islands” in yolk sac.
  • Cells migrate to liver then spleen then bone marrow in foetus.
  • At birth bone marrow is widely distributed then retreating to axial skeleton by adulthood.
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12
Q

Name the three types of granulocytes

A

neutrophils, eosinophils and basophils.

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