Week 8 pt 2 Flashcards
10x risk of African and Caribbean migrants for what condition?
schizophrenia
schizophrenia is associated with mutations in __ out of __ chromosomes
21 out of 23
risk factors for schizophrenia (5)
- man
- older father
- atypical prenatal development
- poor social adjustment
- deficient psychomotor functioning
Minor Physical Anomalies with schizophrenia (3)
- High-steepled palate
- Partial webbing of two middle toes
- Especially wide or narrow-set eyes
__% reduction in life expectancy in schizophrenia
20%
(40% of deaths attributable to suicide)
Symptoms of Anti-Cholinergic (4)
- dry mouth
- urinary retention
- blurred vision
- constipation
4 types of Extrapyramidal (too much antipsychotic)
- Tardive Dyskinesia – symptoms irreversible but Vitamin E can prevent further deterioration
- Akathisia – subjective unpleasant feeling of restlessness
- Pseudo-Parkinsonism
- Acute Dystonia
Medication being studied for people who are treatment resistant with at least 2 antipsychotic meds for schizophrenia
Clozapine
Families of persons with affective disorders are ____ more likely to develop MDD or Bipolar/mood disorder
10 times
trait or genetic predisposition underlying one’s baseline range and lifelong ability to feel pleasure
Hedonic Tone/ Responsiveness
Hedonic Tone/ Responsiveness is caused by
Dysfunction of mesolimbic and mesocortical pathways
LOW Hedonic Tone causes an increased risk for: (3)
anhedonia, depression, and dysthymia
What explains 3-6 week lag in tx response time
Hippocampal neurogenesis
Internalization of sxs and negative emotionality in MALES in childhood is found to be associate with maternal emotional distress in what trimester
first
Increase risk of autism, Tourette’s, OCD, and ADHD is found to be associate with maternal emotional distress in what trimester
first
Internalizing sxs in FEMALE adolescence is found to be associate with maternal emotional distress in what trimester?
third
associated with more fearful and reactive bx in female infants as compared to male infants
Elevated milk cortisol levels during lactation
associated with increased risk of mood disorder in children
Older maternal age
diagnosis with Reduced connections between amygdala and PFC
GAD
Disproportionate activation of amygdala when viewing negative expressions and neutral ones
social anxiety
Increase activation of amygdala & periaqueductal grey during what?
panic attack
Activation in which lobe: “Anxious Apprehension” vs. “Anxious Arousal”
- Anxious App = increased activation in left frontal lobe (i.e., Broca’s)
- Anxious Arousal = increased activation in right temporal lobe (i.e., increased sensitivity to environmental sounds and noises.)
