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S.N Immunology I > Week 8 > Flashcards

Week 8 Flashcards

1
Q

Which TLR recognizes LPS?

A

TLR4

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2
Q

Which cells can make DNA traps?

A

Neutrophils

Eosinophils

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3
Q

What will we see i blood serum in case of bacterial infection

A

Neutrophils

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4
Q

Bacterial infection increases _____ levels

A

Procalcitonin

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5
Q

We will see increase in procalcitonin levels especially in

A

Systemic infection

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6
Q

Innate immunity to IC bacterias

A

Bacterias are resistant to phagocytosis (Bcs they are inside cells!)

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7
Q

Activation of NK by IL__

A

IL12

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8
Q

Adaptive immunity to IC bacterias

A

Th1 (IFN-gamma activates MPH)

CD8 kill infected cells

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9
Q

Granulomas contain

A 
Th1 
MPH
Caseous center
...
...
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10
Q

How IC bacterias escape immunity?

A
  • Phagolysosome inhibition

- Hemolysin production (MPH inhibition)

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11
Q

IC bacteria infection.

What will we see in the blood?

A

Lymphocytosis

Monocytosis

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12
Q

Which parasites can we see in the GI?

A

Helminths

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13
Q

Innate immunity to parasites? (4)

A

Recognition by PRR
Resistant to complement system
MPH
Eosinophils

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14
Q

Which cytotoxic cationic proteins does Eosinophils secretes?

A

E. Peroxidase
E. Cationic Proteins
E. Neurotoxins

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15
Q

Adaptive immunity to parasites? (2)

A

IgE

CD8+ (if protozoa are within cells)

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16
Q

Parasite strategies to escape immunity (3)

A

Some of them survive within cells
Cyst formation
Tegumantum resist Ab

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17
Q

MPH cahanges induces by Helminth

A

NeMac MPH phenotype (M2)

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18
Q

Helminth secretes ___ to inhibit MPH

A

MPH Inhibiting Factor

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19
Q

Patient’s blood with parasite will contain

A

IgE

Eosinophilia

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20
Q

Innate immunity to Fungi (3)

A

Fungicis ROS
Lysosomal enzymes
Phagocytosis

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21
Q

PAMP of Fungi (3)

A

Zysoman
Mannan
B-glycan

22
Q

DC secrete __ to recruit __ and ___

A

IL23

Th17 and ILC3

23
Q

Adaptive immunity to Fungi?

A

Th1
Th17
+ Same as to IC bacterias

24
Q

Strategies of Fungi to escape immunity

A

Unknown

25
Q

Blood of patient with Fungi

A

Neutrophilia

When chronic, also Monocytosis

26
Q

Innate immunity against Viruses

Type 1

A

IFN-a

IFN-b

27
Q

IFN-a are produced by

A

Leukocytes

28
Q

IFN-b are produced by

A

Fibroblasts

29
Q

Innate immunity against Viruses

Type 2

A

IFN- gamma

30
Q

IFN- gamma are produced by

A

NK cells (ICL1)

31
Q

Viruses PAMP recognition (3)

A

GP by TLR2,4
DNA by TLR9
RNA by TLR3, 7/8

32
Q

Adaptive immunity to Viruses

A

Th2 secrete Ab

Prevent spread

33
Q

Cellular immunity to viruses by

A

CD8+ T cells and CD4+ Th1 cells

34
Q

Which cytokines provide early defense against viruses infection? (3)

A

TNF-a
IL12
IFN-a

35
Q

Stractual plasticity is achieved by (2)

A

Ag drift

Ag shift

36
Q

Ag drift

A

After virus passage in the host, slightly modified Ag appears

37
Q

Ag shift

A

New gene bcs gene exchange btw two viruses

38
Q

HIV effect on Immunity

A

Induces internalization of CD4 and MHC1/2

39
Q

EBV effect on Immunity

A

Physical blocking of MHC2

40
Q

HIV-1 increases ___ expression of the infected cell

A

FasL

41
Q

Tissues with no inflammation

A

CNS and eyes

42
Q

Virus infected patients will have ____ in their blood

A

Lymphocytosis

43
Q

Secondary immuno deficiency is __% of all immuno deficiency

A

90%

44
Q

Primary immuno deficiency of T cell examples

A

SCID

DiGeorge

45
Q

Primary immuno deficiency of Phagocytes examples

A

Chronic granulomatous disease

46
Q

Hyper IgM syndrome- what we will see

A

Patient is unable to switch IgM to IgG, IgA, IgE

Recurrent pyogenic infection

47
Q

Cause of Hyper IgM syndrome

A

Lack of T cell CD40L

48
Q

Job of CD40L

A

Induces class switch

49
Q

Classical pathway deficiency leads to

A

Immuno-complex disease

50
Q

MBL pathway deficiency leads to

A

Bacterial infections mainly in childhood

51
Q

Alternative pathway deficiency leads to

A

Neisseria and Pyogenic infections

52
Q

____ drops below threshold in AIDS

A

CD4+

S.N Immunology I (16 decks)

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