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S.N Immunology I > Week 11 > Flashcards

Week 11 Flashcards

1
Q

NALT meaning

A

Nasopharynx Assosiated Lymph Tissue

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2
Q

Mucosa immunity includes

A

MALT
NALT
GALT

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3
Q

How many of all lymphocytes founs in the mucosa?

A

3/4

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4
Q

Payers patch: what can we find in the SED

A

(Sub Epithelial Dome)

Dendritic Cells

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5
Q

Payers patch: what can we find in the TDA

A

(T Dependent Area)

T cells around follicles of B cells

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6
Q

M cells function

A

Above Payer patches

Contineous Ag uptake

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7
Q

M cells take up Ag by

A

Endocytosis

Phagocytosis

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8
Q

How else can DC capture Ag frok the lumen?

A

Extend processes across the epithelial layer to capture Ag from guts lumen

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9
Q

What is the ligand for CCR9?

A

CCL25

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10
Q

MACDAM binds

A

a4b7 integrin

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11
Q

Two compartments of the mucosal immune system

A

Epithelium

Lamina propria

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12
Q

Which T cell is present on the Lamina propria?

A

CD4

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13
Q

Which T cell is present on the Epithelium?

A

CD8

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14
Q

Intra Epithelial Lymphocytes

A

CD8 T cells
50% gamma-delta-T
Many NK cells

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15
Q

IgA appears as ____ in the blood

A

Monomer

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16
Q

IgA appears as ____ on the mucosa

A

Dimer

17
Q

Which cytokines will induce the formation of IgA producing cells

A

IL2
IL5
TGF b

18
Q

TLR location in the gut?

A

Balolateral surface (Dimeric TLR)
IC (Monomeric NLR)
DC (Low levels of TLR)

19
Q

Endosome have TLR number

A

TLR-9

20
Q

Balolateral surface have TLR number

A

TLR-5

21
Q

NLR action

A

Caspase-1

Activation of IL-1

22
Q

CD11b + DC activates

A

Th17

23
Q

CD103 + DC activates

A

Treg

24
Q

Naturally present bacteria in the dental plaque

A

Fusobacterium nucleatum

25
Q

Bacteria present in periodontitis

A

Porphyromonas gingivalis

26
Q

Fusobacterium nucleatum promotes ______ expression

A

B Defensin

Fusobacterium nucleatum is resistant agains B defensin but Porphyromonas gingivalis NOT!

27
Q

Where else can we find Porphyromonas gingivalis in case of periodontitis?

A

Atheromatous plaque

S.N Immunology I (16 decks)

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