Week 5 Flashcards
1
Q
Define Affinity
A
Strength of a single Ab-Ag interaction
2
Q
Define Avidity
A
Strength of all interactions combined
3
Q
TCR is present in which forms (soluble/Non-soluble)
A
Only in Non-soluble - transmembrane Ag-R
4
Q
TCR complex consist of
A
CD3 * 2
TCR
5
Q
BCR complex consist of
A
BCR
Ig-beta
Ig-alpha
6
Q
What holds togather multimeric Ag?
A
J chain
7
Q
Light chains are ___ or ___
A
Kappa
Lambda
8
Q
Different indeviduals have different ____
A
Allotypes
9
Q
Which enzyme cleavs Ab into Fab and Fc?
A
Papain
10
Q
CDR meaning
A
Complementarity Determining Region
11
Q
Which CDR attaches the residue of peptide (Ag)?
A
CDR3
12
Q
Number of VDJ options
A
V- 51
D- 27
J- 6
13
Q
Rearrangement is mediated by ___
A
RAG1/RAG2
14
Q
RAG is only expressed in
A
Developing lymphocytes
15
Q
Which enzyme enables the phenomenon of junctional diversity?
A
TdT
