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S.N Immunology I > Week 3 Lecture > Flashcards

Week 3 Lecture Flashcards

1
Q

First complement component is

A

C1

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2
Q

Complement activation has __ pathways:

A

3
Classical
Lectin
Alternative

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3
Q

c3b cleaves (2)

A

c3 (positive feedback)

c5

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4
Q

The classical complement pathway is initiated by __________________ with the antibody isotypes ___ , ___

A

antigen-antibody complexes

IgG and IgM

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5
Q

What are the components of classical C3 convertase?

A

C4bC2b

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6
Q

Which enzyme cleaves C3?

A

C4bC2b (C3 convertase)

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7
Q

What are the components of C5 convertase?

A

C4bC2bC3b

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8
Q

What are the components of the membrane attack complex?

A

Poly C9

C5b678

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9
Q

What binds the Ag Ab complex in the Classical pathway?

A

C1qrs

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10
Q

Lectin pathway has the ability to bind ____

A

Sugar

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11
Q

In contrast to the classical complement pathway, the lectin pathway does not __________________

A

recognize an Ab-Ag

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12
Q

The lectin pathway starts with __________________

A

Mannose-Binding Lectin or Ficolin

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13
Q

Multimers of MBL form a complex with _____

A

MASP-1 or MASP-2

Mannose-binding lectin-Associated Serine Protease

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14
Q

MASPs are very similar to _________ molecules of the classical complement pathway

A

C1r and C1s

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15
Q

When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-1 and MASP-2 are activated to cleave complement components ________

A

C4 and C2

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16
Q

The Alternative pathway is triggered when __________________________

A

the C3b protein directly binds a microbe

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17
Q

What is the job of factor D in the Alternative pathway?

A

factor D cleaves C3b+B into C3b+Bb

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18
Q

What is the regulator of complement activation that stabilizes the alternative pathway convertases

A

Properdin

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19
Q

What is the C5 convertase in case of the Alternative pathway?

A

C3bBbC3b

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20
Q

What innitiates the Alternative pathway?

A

Spontaneous hydrolysis of C3

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21
Q

_____ _____ are Anaphylatoxins

A

C3a

C5a

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22
Q

The membrane-attack complex (MAC) forms_______ .

A

transmembrane channels

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23
Q

Other name for CR2

A

CD21

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24
Q

CR2 binds

A

C3dg- opsonized Ag

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25
Q

CR3, CR4 binds

A

iC3b

Participate in Phagocytosis

26
Q

What is the inhibitor of the classical pathway?

A

C1INA (Plasma protein)

27
Q

What are the inhibitors of the C3 convertase?

A

I factor (in the plasma)
DAF (Decay Accelerating factor)
MCP (Membrane Co-factor Protein)

28
Q

How can we inactivate Anaphylatoxins?

A

cleavage of C3a ans C5a By Serum Carboxypeptidase

29
Q

How can we inhibit the MAC?

A

Protectin (CD59) - Lymphocyte surface molecule

30
Q

What is the most frequent withborn complement deficiency?

A

C2

31
Q

C1 Inh deficiency leads to

A

Hereditary angioneurotic edema (HANO,HAE)

32
Q

Hereditary angioneurotic edema (HANO,HAE) is due to

A

C1 Inh deficiency

33
Q

What is the effect of C1 in immune regulation?

A

In the absence of C1 Inh, spontaneous classical activation of C4 and C2 cleavage

34
Q

What other systems are affected by C1 Inh?

A

In its absence, there is increased bradykinin synthesis

35
Q

C1 is made of

A

DImerX3 with C1r and C1s

36
Q

C1 cleaves

A

C4 and C2

37
Q

Membrane attack coplex=

A

C5b678+Poly C9

38
Q

In the alternative pathway, C3b binds

A

Factor B

39
Q

C3bB is cleaves by ____ to produce ____

A

Factor D

C3bBb+Properdin

40
Q

C3bBb cleaves ___ to produce ____

A

C3

C3bBbC3b

41
Q

Which C3 binds complement receptors and enhance phagocytosis?

A

C3b
C3bi
C3dg

42
Q

Which receptor on RBC recognize C3b+Ag+Ab?

A

CR1

43
Q

CR2 is located on

A

B cells

44
Q

CR2 recognize ___

A

C3dg

45
Q

CR2 - C3dg participate in

A

B cell activation

46
Q

CR3, CR4 integrin receptors bind ___ and participate in ____

A

iC3b

Phagocytosis

47
Q

Inhibition of classical pathway

A

C1 inhibitor

48
Q

C3 convertase inhibition

A

I factor
DAF
MCP

49
Q

Inactivation of Anaphylatoxins by

A

SCPN
Serum Carboxy-Peptidase N
cleave C3a and C5a

50
Q

Inhibition of MAC by

A

Protectin

51
Q

Other name for protectin

A

CD59

52
Q

MASP

A

Mannosie Assosiated Serine Protease

53
Q

Mot common withborn complement deficiency?

A

C2

54
Q

Early complement deficiency leads to

A

Autoimmune disease

55
Q

Late complement deficiency leads to

A

Pyogenes and Neisseria infections

56
Q

C1 inh. deficiency leads to

A

Hereditary Angioneuretic Edema

57
Q

What happens in the absence of C1 inhibitor?

A

Spontaneous classical activation and C4 / C2 cleavage

58
Q

Location of C3 convertase genes

A

MHC III in HLA region

59
Q

Positive gene expression of acute plasma proteins examples

A 
B factor
C3 Fibrinogen
C1 inhibitor
CRP
SAA (Serum Amyloid A)
60
Q

Negative gene expression of acute plasma proteins examples

A

Transferrin
Abumin
Fibronectin

61
Q

Biological functions of acute phase proteins

A

Silencing Infllammatory signals
Reducing inflammation
Homeostasis

S.N Immunology I (16 decks)

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