Week 14- Cancer Flashcards
1
Q
Immunological evolution of tumorigenesis (4 phases)
A
Tumorigenesis
Elimination
Equilibrium
Escape
2
Q
Most important factors of elimination (6)
A
NK T gamma delta CD8+ DC MPH (1) Ab
3
Q
NK and T gamma delta activation via ____
A
NKG2D
4
Q
Danger signals recognized by DC’s
A
EC DNA EC RNA Urea crystals HSP70 HSP90
5
Q
NK and T gamma delta can eliminate tumor cells via (5)
A
TNF IFN a IFN b IFN gamma Perforin/Granzyme
6
Q
MPH (M1) can eliminate tumor cells via (2)
A
ROS
TNF secretion
7
Q
_____ are the main effectors of anti-tumor imunity
A
CD8+ T cells
8
Q
Cross presentation=
A
Under special conditions APC may present exogenous Ag with MHC-1 to CD8+ T cell
9
Q
What abnormal infammatory infiltrates can we see in case of chronic inflammation
A
M2 MPH MDSC-k Mast cells CD25 Treg Immature DC Immuno-complex deposition
10
Q
Tumor escape happens through T cell inhibition by _______ (cytokines)
A
IL10
TGF-b
VEGF
IDO
11
Q
Mab=
A
Monoclonal Ab
12
Q
Li=
A
Immune system
13
Q
Ki=
A
Interleukin
14
Q
tu=
A
Tumor
15
Q
O=
A
Mouse
