Week 12- Autoimmunity Flashcards
1
Q
Immunotolerance=
A
Recognize the self Ag but dont react with it
2
Q
Autoimmunity=
A
Recognize the self Ag and react with it
3
Q
CD5+ =
A
B1 B cells
4
Q
B1 B cells=
A
CD5+
5
Q
Central tolerance takes place in
A
Primary lymphoid organs
6
Q
Anergy=
A
Inability to induce immune response in the absence of co-stimulation
7
Q
Pathological immunity developes if
A
the immuno tolerance is broken or insufficient
8
Q
Negative selection of T cells
A
Apoptosis if- T cell recognize self peptide MHC complex with high avidity
9
Q
Ignorance=
A
Low avidity TCR binding
10
Q
Immunoprivileged sites
A
Eye Brain Testis Pregnant uterus Thyroid
11
Q
Possible mechanism inducing autoimmunity (4)
A
Molecular mimicry
Over expression of MHC2
Superantigen
Polyclonal B-cell activation
