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S.N Immunology I > Practice Q > Flashcards

Practice Q Flashcards

1
Q

How many AA can MHC I present

A

8-9

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2
Q

How many AA can MHC II present

A

15-25

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3
Q

B2-microglobulin is present on chromosome __

A

15

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4
Q

Haplotype=

A

Combination of alleles at adjacent locations on chromosome that are transmitted togather

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5
Q

Locus of HLA is detemined as

A

Capital letter

HLA-A

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6
Q

Allele of HLA is determined by

A

Number

HLA-A7

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7
Q

Which HLA is the most important to check in case of kidney transplantation?

A

HLA-DR

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8
Q

Most important autoAb in autoimmune disorders (5)

A 
ANA
ANCA
Anti=phospholipid Ab
RF
ACPA
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9
Q

RF means

A

Rheumatoid Factor

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10
Q

ANA binds

A

Contents of the cell nucleus

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11
Q

ANA means

A

Anti Nuclear Ab

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12
Q

RF mechanism

A

RF is an Ab against the Fc fragments of IgG

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13
Q

ANCA means

A

Anti Neutrophil Cytoplasmic Ab

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14
Q

Reaction in Type II HSN

A

Cell or matrix associated Ag connectig IgG

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15
Q

Which HSN are mediated by IgG?

A

II

III

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16
Q

Myasthania Gravis is type __ HSN

A

II

17
Q

Myasthania Gravis mechanism

A

Ab against Ach receptors

18
Q

Basedow disease mechanism

A

Stimulatory Ab against TSH-R

19
Q

Direct Coombs test=

A

Detects Ab on cell surface

20
Q

Indirect Coombs test=

A

Detects free Ab

21
Q

Describe indirect coombs test

A 
We take mather serum with the Rh+ Ab
We add baby Rh+ RBC
Mothers Ab attach to RBC Rh+ Ag
We add anti-human Ab
Agglutination
22
Q

Ag in case of Celiac disease

A

Gliadin (grain protein)

23
Q

Type IV HSN happens after __

A

2-3 days

24
Q

Effects of Histamine on H1-R

A

Increased mucosa secretion
Increased vascular permaebility
Airway constraction

25
Q

Effects of Histamine on H2-R

A

Vasodilation

Airway mucus secretion

26
Q

Effects of Histamine on H4-R

A

Itch

Inflammatory cells recruitment

27
Q

What else is released from mast cells?

A

Prostaglandins
Proteases
Heparin

28
Q

Which cells release Histamine?

A

Mast cells

Basophils

29
Q

Anaphylactic=

A

IgE mediated

30
Q

Anaphylactoid=

A

Direct mast cell secretion

31
Q

Anaphylactoid can happen when

A

Eating high Histmine containing foods like red wine

32
Q

Mechanism of HAE

A

C1 inhibitor deficiency

33
Q

HAE mediator

A

Braykinin

34
Q

Which enzzyme will we detect in serum in case of allergy and why?

A

Tryptase

Bcs. it is released of Mast cells along Histamine

S.N Immunology I (16 decks)

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