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S.N Immunology I > Week 13- Transplantation > Flashcards

Week 13- Transplantation Flashcards

1
Q

Graft=

A

Transplanted cells, tissue or organ

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2
Q

Ortotopic transplantation=

A

Graft is placed to the original anatomic location

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3
Q

Heterotropic transplantation=

A

Graft is placed to the different anatomic location

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4
Q

Autotransplantation=

A

Donor and recipient are the same person

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5
Q

Most transplanted orans (4)

A

Kidney
Liver
Heart
Lung

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6
Q

Most frequent transplantation is

A

Transfusion

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7
Q

Allograft=

A

Different person is the Donor

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8
Q

Isograft/Sygraft=

A

Monozygotic twins

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9
Q

Autograft=

A

Donor and recipient are the same person

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10
Q

Xenograft=

A

Donor is an animal

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11
Q

Which MHC gene must be same for donor and patient

A

HLA-A
HLA-B
HLA-DR

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12
Q

Significance of matching blood types

A

Blood group Ag are also present on blood vessel endothelial cells as part of the donor tissue

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13
Q

No cytoablation is seen in ______ transplantation

A

Organ

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14
Q

____ therapy is needed in case of Organ transplantation

A

Suppressive

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15
Q

HLA matching is critical in case of ____ transplantation

A

Bone marrow

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16
Q

______ is necessary in case of bone marrow transplantation

A

Cytoablation

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17
Q

Major complication in case of bone marrow transplantation

A

GVHD

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18
Q

Major complication in case of organ transplantation

A

Rejection

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19
Q

Allograft=

A

Different person is the Donor

20
Q

Host vs Graft reaction in case of

A

Transplantion of Non-immunocometent tissues

21
Q

non-immunocometent tissues examples (3)

A

Kidney
Liver
Skin

22
Q

Graft vs Host reaction in case of

A

Transplantion of Immunocometent tissues

23
Q

Immunocometent tissues examples

A

HSC
Thymus
Spleen
But also- Lung, Liver, Gut

24
Q

HVG means

A

Rejection

25
Q

GVH means

A

Defenceless recipient

The donor cells attack the cells left of the donor. Can be a good thing!!! if the patients own cells are bad

26
Q

1 year survival of liver transplantation

A

> 75%

27
Q

Heart transplantation carried out if the expected one year survival is

A

Less than 50%

28
Q

5 years survival of heart transplantation

A

80%

29
Q

5 years survival of liver transplantation

A

70%

30
Q

1 year survival of pancreas transplantation

A

72%

31
Q

Langerhans island transplantation

A

Islets established in liver sinusoids

32
Q

Cornea transplantation

A

60-70% acceptance

33
Q

Direct recognition role in rejection

A

Acute rejection

34
Q

Indirect recognition role in rejection

A

Chronic rejection

35
Q

Extent of rejection in Direct recognition

A

Intense

36
Q

Extent of rejection in Inirect recognition

A

MildIndirect recognition

37
Q

Direct recognition=

A

Recognition of allogenic MHC/peptide complex on the surface of donor APC within the graft

38
Q

Indirect recognition=

A

Recognition of allogenic donor MHC molecule derived peptdie epitope by recipient (patients) APC’s

39
Q

Which Ag play a role in hyperacute rejection? (3)

A

ABO blood Ag
VEC (vascular endot. cell) Ag
HLA Ag

40
Q

Origin of HLA sensitization

A

Transfusion
Pregnancy
…

41
Q

Acute rejection happens ___ after transplantation

A

Weeks to months (mostly 1 month after)

42
Q

Significans of chronic rejection

A

Fibrosis

43
Q

Mechanism of chronic rejection

A

CD4+ T cells

MPH

44
Q

How can we prevent transplantation rejection?

A 
Steroid infusion
Anti-CD28
Anti-MHC2
Anti-CD4
Immunosuppression
Donor selection
45
Q

Acute GVHR is life threatening in case of

A

Endothelial cell death in GI tract which can lead to GI tract bleeding

S.N Immunology I (16 decks)

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