Week 6

Question 1

2 types of TCR

Answer 1

alpha, beta - 95%

gamma, delta - 5%

Question 2

Killer T cell is also called

Answer 2

Cytotoxic

Question 3

In the cortex of thymus there is ____ selection

Answer 3

Positive

Question 4

In the medulla of thymus there is ____ selection

Answer 4

Negative

Question 5

Where do T cells develope?

Answer 5

Bone marrow

Question 6

Cells expressing gamma-delta-TCR arise firstly in

Answer 6

Embryonic development

Question 7

Is there a selection process in gamma-delta-TCR?

Answer 7

No

Question 8

What is needed for selection of apha-beta-T cell?

Answer 8

Recognition of self MHC

NOT recognizing self Ag

Question 9

Positive selection aim

Answer 9

Recognize self MHC+peptide

If weak binding- Apoptosis

Question 10

AIRE controls?

Answer 10

Expression of self peptides by thymic medullary epithelial cells

Question 11

Negative selection aim

Answer 11

DIfferentiate self and foreign Ag

Question 12

How many survive positive selection?

Answer 12

45%

Question 13

How many survive negative selection?

Answer 13

5%

Question 14

When do T cell activate?

Answer 14

When they encounter their specific Ag

Question 15

Dendritic cells migrate via ____ to regional lymph nodes

Answer 15

Afferent lymphatics

Question 16

Costimularion of T cells happens when

Answer 16

B7 (APC)

CD28 (T cell)

Question 17

What phosphorylates CD3 ITAM motif?

Answer 17

B7-CD28 interaction

CD4+Kinase

Question 18

Describe IL2

Answer 18

Autocrine T cell GF

Induces T cell proliferation

Question 19

IL2-R mutation can cause

Answer 19

SCID (Severe Combined Immuno-Deficiency

Question 20

Describe the negative costimulation

Answer 20

B7
CTLA4

Down regulates immune response

Question 21

B7 is also called

Answer 21

CD80

Question 22

Major site of action of CTLA4

Answer 22

Lymphoid organs

Question 23

alpha-beta-T memory cells types

Answer 23

T cm (central memory)
T em (effector memory)

Question 24

CD4 can be ___ or ___

Answer 24

Helper

Regulatory

Question 25

CD8- CD4- cann differentiate to (3)

Answer 25

gamma-delta-T cell
NKT
CD8+CD4+

Question 26

T regulatory secretes

Answer 26

TGF b

IL10

Question 27

Th1 secretes

Answer 27

IFN gamma
TNF a
IL2

Question 28

Th2 secretes

Answer 28

IL4
IL5
IL10
IL13

Question 29

Granules of CD8 T cell contain

Answer 29

Perforin

Granzyme

Question 30

IL4 function

Answer 30

Activates Th2

Inhibit Th1

Question 31

If CD4 naive T cell becomes Th1 where does it migrate to

Answer 31

Periphery

Question 32

If CD4 naive T cell becomes Th2 what will happen next

Answer 32

Activates B cells

Question 33

gamma-delta-T function

Answer 33

Migrate to mucosa and cutaneous tissues

First line defense

Question 34

gamma-delta-T Ag is restricted to Mhc recognition T/F

Answer 34

False