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S.N Immunology I > Week 1+2 Q > Flashcards

Week 1+2 Q Flashcards

1
Q

What do T cells recognize?

A

Linear peptide sequence in the groove of the MHC

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2
Q

Primary immune response characteristics

A

Slow
Low A
IgM אני מגיע ראשון

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3
Q

Secondary immune response characteristics

A

Fast
High A
IgG

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4
Q

Natural immunity also clled

A

Innate

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5
Q

Molecule systems of Innate immunity

A

Soluble antimicrobial molecules
Natural Ab
Complement system

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6
Q

Defensins act as

A

Direct cytotoxicity

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7
Q

Defensins are expressed in

A

Salivary glands
Paneth cells
Leukocytes

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8
Q

Most Defensins are _____ molecules

A

Amphipatic

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9
Q

Job o Defensins

A

Attach the membrane
Bend the membrane
Create pore
Internal content release

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10
Q

Where can we find alpha-Defensins?

A

Neut.
Inflammation site
Salivary duct cells

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11
Q

Where can we find Beta-Defensins?

A

Epithelia

Salivary duct

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12
Q

How do Lysozyme destroy bacterial cell wall?

A

Breaking glycosidil bonds btw. peptydoglycan components

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13
Q

What can cause deprivation of bcterial nutrients?

A

Calprotectin

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14
Q

Recruited MPH activation types

A

M1

M2

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15
Q

M1=

A

Classically activated

Inflammatory cytokines

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16
Q

M2=

A

Alternatively activated

Suppression host defence

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17
Q

What are the three modes of intracellular killling

A
  1. Lysosomal antibacterial substance
  2. O2 dependent respiratory burst
  3. NO mediated
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18
Q

CGD means

A

Chronic Granulomatous Disease

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19
Q

CGD happens bcs.

A

Lack of oxidase in phagocytes

Causes recurrent infections

20
Q

NK cell is a type __ which produce ____

A

1

IFN-gamma

21
Q

NK kill ____ and ____

A

Virus infected cells

Tumor cells

22
Q

Dual receptor system of NK consist of

A

Killer Inhibitory Receptor (KIR)

Killer Activating Receptor (KAR)

23
Q

KAR binds

A

Ubiquitous molecule

24
Q

KIR binds

A

MHC 1

25
Q

WHen will NK cell kill something?

A

When KAR binds Ubiquitous molecule
BUT
KIR is free (Bcs. no MHC 1 !! - not own body cell)

26
Q

Example for KIR

A

NKG2A

27
Q

Example for KAR

A

NKG2D

28
Q

ADCC means

A

Ab Dependent Cellular Cytotoxicity

29
Q

What happens in ADCC

A

Effector cell of immune system lyses a target cell, whose memb. surface Ag have been bound by specific Ab

30
Q

Which molecule on NK cells is involved in ADCC?

A

CD16

31
Q

Phagocytes Receptors

A
  1. Opsonic -R

2. PRR

32
Q

Example for Opsonic -R

A

Fc-R

Complement-R

33
Q

Fc-gamma binds

A

IgG

like daaa g-G

34
Q

Where can we find CD14

A

Mostly MPH

35
Q

CD14 job

A

Binds bacterial LPS (PAMP)

36
Q

Membrane PRR examples

A 
Scavenger
Lectin
COmplement
NK cell
TLR
37
Q

Which TLR recognize LPS?

A

TLR4

38
Q

TLR function as monomer T/F

A

False. They function as Dimer

39
Q

Nucleic acids are recognized by TLR in ______

A

Endosomes

40
Q

Which receptors recognize intracellular bacterias?

A

NLR (Nod Like R)

41
Q

Which receptors recognize virus?

A

RLR (RIg Like R)

42
Q

Ligand binding to TLR activates the transcription of ___

A

NF-kB

43
Q

Which receptor on MPH is a LPS-R?

A

CD14

44
Q

NF-kB will control the transcription of

A

IL-1 betta

IL-18

45
Q

Necrotic ceall death will release ___

A

DAMP (Damage Assosiated Molecular Pattern)

46
Q

What are DAMP’s?

A

Molecules release upon necrosis

Trigger generation of EC pro inflammatory molecules

47
Q

Inflammasome is made of

A

NLR
ASC
Caspase 1

S.N Immunology I (16 decks)

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