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S.N Immunology I > Week 4 lecture > Flashcards

Week 4 lecture Flashcards

1
Q

Exogenous Ag are presented by

A

MHC II

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2
Q

Endogenous Ag are presented by

A

MHC I

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3
Q

MHC gene is on chromosome

A

6
Short arm
(MHCix. c sounds like si-six)

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4
Q

Antigen binding domain of MHC I is composed of

A

α1 and α2 domains

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5
Q

Antigen binding domain of MHC II is composed of

A

α1 and β1 domains

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6
Q

MHC I is present where?

A

All nucleated cells

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7
Q

MHC II is present where?

A

DC
B cell
MPH

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8
Q

MHC I has a ____ pocket and MHC II has an ____ pocket

close/open

A

MHC I has a closed pocket and MHC II has an open pocket

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9
Q

Low expression of MHC on which cells?

A

Fibroblasts
Muscle cells
Liver cells

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10
Q

How does the degraded endogenous proteins get to to the ER?

A

Through TAP1/TAP2

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11
Q

TAP meaning

A

Transporters Associated with Ag Processing

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12
Q

Which system trims peptides in the lumen of the ER?

A

ERAP

Aminopeptidase associated eith Ag processing in the ER

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13
Q

What transforms constitutive proteasome to immunoproteasome

A

IFN gamma

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14
Q

The genetic code of the TAP proteins is located within the _____ region

A

MHC II

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15
Q

What can happen in TAP deficiency?

A

Necrotizing Granulomatous

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16
Q

Cathepsin B is activated by ____

A

Low pH

17
Q

What catalyze the removal of CLIP?

A

HLA-DM and HLA-DO

18
Q

CLIP is a part of the __________

A

Invariant chain

19
Q

Invariat chain is present in ____

A

MHC II

20
Q

What presents lipid Ag?

A

CD1

21
Q

What is needed in oeder to activate naive T cells?

A

MHC-peptide complex

Costimulation

22
Q

Activated Th cells produce ___

A

IL2

23
Q

Where does cross-presentation happens?

A

CD8+ DC’s only

24
Q

How many different types of MHC can an APC cells express?

A

12

25
Q

Which HLA is expressed on Trophoblast cells?

A

HLA-G

26
Q

Position __ in the DQ-beta chain affects susceptability to ___

A

57

Insulin Dependent DM

S.N Immunology I (16 decks)

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