Week 2 - Hc. 6: Chronische en acute pancreatitis Flashcards
1
Q
Pancreas functie
A
- Bloed glucose regulatie
- Digestie
2
Q
Acute pancreatitis
A
- Incidence: 70-700 per 1.000.000
- Severe attacks in 10-20% of cases
- Mortality: 9%
- Geen gevolgen op de pancreas wanneer genezen
3
Q
Chronische pancreatitis
A
- Prevalence: 0,04-5%
- Mortality: up to 50% over 25 years
- Litteken vorming
4
Q
Clinical presentation acute pancreatitis
A
- Severe epigastric pain
- Radiating to the back
- Nausea and vomiting
- In cas of biliary origin sometimes precedes by colic pain
- 6-12 hours after binge drinking
5
Q
Biliary pancreatitis
A
Pancreatitis veroorzaakt door een galsteen in het papil van Vater
6
Q
Diagnose acute pancreatitis
A
Clinical feature and serum amylase and/or lipase 3 times upper limit of normal
7
Q
Oorzaken van acute pancreatitis
A
- Obstruction
- Toxins or drugs
- Trauma
- Metabolic abnormalities
- Inherited conditions
- Infections
- Vascular abnormalities
- Miscellaneous conditions
8
Q
Waarom vindt de ontsteking plaats bij pancreatitis
A
The pancreatic enzyme cascade -> zelf digestie
9
Q
Behandeling pancreatitis
A
- Supportive
- Remove cause
- IC
- Endoscopic treatment
- Radiologic interventions
- Surgery
10
Q
Etiologische factoren van chronische pancreatitis
A
- Toxic metabolic
- Medications
- Toxins
- Idiopathic
- Genetic
- Autoimmune
- Recurrent and severe pancreatitis
- Obstructive
11
Q
Prognose chronische pancreatitis
A
- Disease with serious consequences
- Excess mortality compared to general population: 15-20% directly related to disease and it’s complications; 80-85% indirectly related causes such as malnutrition, alcoholic liver disease, trauma, smoking
- Increased risk for developing pancreatic cancer: 4% per 20 years
12
Q
Behandeling chronische pancreatitis
A
Pijn
- Medicatie
- Endoscopisch
- Chirurgie
Exocriene insufficiëntie:
- Pancreatic enzyme supplementation
Endocriene insufficiëntie:
- Insuline
Pseudocysts
- Endoscopisch
- Chirurgie
