We - iNKT cells and T cells in anti-tumor immunity

Question 1

What is the difference between conventional and unconventional T cells?

Answer 1

The MHC molecule subclass that the cells recognise

Question 2

Why is the response from unconventional T cells on an infection much faster than conventional T cells?

Answer 2

Unconventional T cells don’t require priming from APC cells

Question 3

Are NKT cells conventional, or unconventional T cells?

Answer 3

Unconventional

Question 4

NKT cells in cancer are (reduced/heightened)

Answer 4

Reduced

Question 5

True or false: NKT Cell amount can predicts survival, higher numbers = better prognosis

Answer 5

True

Question 6

Gamma delta T cells are (conventional/unconventional) T cells

Answer 6

Unconventional

Question 7

True or false: high numbers of tumor infiltrating gamma delta-2 T cells leads to better clinical outcome

Answer 7

True

Question 8

Why are tumor cells more prone to be targeted by gamma delta T cells? (explain complicated)

Answer 8

Tumor cells are more prone to be targeted by gamma delta T cells because they accumulate phosphoantigens, and gamma delta-2 T cells are activated by cells with accumulated phosphoantigens.